Effects of Selective and Nonselective Nonsteroidal Anti-inflammatory Drugs on Antibiotic Efficacy of Experimental Group A Streptococcal Myonecrosis

被引：44
作者：
Hamilton, Stephanie M. [1 ]
Bayer, Clifford R. [1 ]
Stevens, Dennis L. [1 ,2 ]
Bryant, Amy E. [1 ,2 ]
机构：
[1] US Dept Vet Affairs, Off Res & Dev, Boise, ID USA
[2] Univ Washington Sch Med, Seattle, WA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Streptococcus pyogenes; myonecrosis; NSAIDs; SOFT-TISSUE INFECTIONS; TOXIC-SHOCK-SYNDROME; NECROTIZING FASCIITIS; PRIMARY VARICELLA; MICE; PENICILLIN; PYOGENES; SUSCEPTIBILITY; INHIBITION; EXPRESSION;
D O I：
10.1093/infdis/jit594
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. Epidemiologic evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) contribute to more severe group A streptococcal (GAS) infections, yet a beneficial role for NSAIDs has been demonstrated in other experimental bacterial infections. Methods. Nonselective (ketorolac tromethamine, ibuprofen, indomethacin), COX-1-selective (SC-560), or COX-2-selective (SC-236) NSAIDs +/- antibiotics (penicillin, clindamycin) were given to mice challenged intramuscularly with M-type 3 GAS and disease course was followed for 14 days. Results. All nonselective NSAIDs significantly accelerated mortality and reduced antibiotic efficacy; COX-selective NSAIDs had no significant effects. Conclusions. Use of nonselective NSAIDs, either alone or as adjuncts to antibiotic therapy, for GAS soft tissue infection may contribute to worse outcomes.
引用
收藏
页码：1429 / 1435
页数：7
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