Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

被引：210
作者：
McIntosh, John A. [1 ]
Donia, Mohamed S. [1 ]
Schmidt, Eric W. [1 ]
机构：
[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
来源：
NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 04期
关键词：
BIOSYNTHETIC GENE-CLUSTER; STAPHYLOCOCCUS-AUREUS VIRULENCE; PROMOTES SECONDARY METABOLISM; ASSEMBLY-LINE ENZYMOLOGY; AMINO-ACID SUBSTITUTIONS; STREPTOCOCCUS-MUTANS T8; LANTIBIOTIC MUTACIN II; SBO-ALB LOCUS; BACILLUS-SUBTILIS; POSTTRANSLATIONAL MODIFICATION;
D O I：
10.1039/b714132g
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribosomally synthesized bacterial natural products rival the nonribosomal peptides in their structural and functional diversity. The last decade has seen substantial progress in the identification and characterization of biosynthetic pathways leading to ribosomal peptide natural products with new and unusual structural motifs. In some of these cases, the motifs are similar to those found in nonribosomal peptides, and many are constructed by convergent or even paralogous enzymes. Here, we summarize the major structural and biosynthetic categories of ribosomally synthesized bacterial natural products and, where applicable, compare them to their homologs from nonribosomal biosynthesis.
引用
收藏
页码：537 / 559
页数：23
相关论文
共 386 条
[61]   Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: The importance of the cyclic cystine knot [J].
Colgrave, ML ;
Craik, DJ .
BIOCHEMISTRY, 2004, 43 (20) :5965-5975
[62]   Copper(II) coordination chemistry of westiellamide and its imidazole, oxazole, and thiazole analogues [J].
Comba, Peter ;
Gahan, Lawrence R. ;
Haberhauer, Gebhard ;
Hanson, Graeme R. ;
Noble, Christopher J. ;
Seibold, Bjoern ;
van den Brenk, Anna L. .
CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (14) :4393-4403
[63]   Activation of subtilin precursors by Bacillus subtilis extracellular serine proteases subtilisin (AprE), WprA, and Vpr [J].
Corvey, C ;
Stein, T ;
Düsterhus, S ;
Karas, M ;
Entian, KD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (01) :48-54
[64]   Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design [J].
Cotter, Paul D. ;
Deegan, Lucy H. ;
Lawton, Elaine M. ;
Draper, Lorraine A. ;
O'Connor, Paula M. ;
Hill, Colin ;
Ross, R. Paul .
MOLECULAR MICROBIOLOGY, 2006, 62 (03) :735-747
[65]   Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147 [J].
Cotter, PD ;
O'Connor, PM ;
Draper, LA ;
Lawton, EM ;
Deegan, LH ;
Hill, C ;
Ross, RP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) :18584-18589
[66]   Bacteriocins: Developing innate immunity for food [J].
Cotter, PD ;
Hill, C ;
Ross, RP .
NATURE REVIEWS MICROBIOLOGY, 2005, 3 (10) :777-788
[67]   Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif [J].
Craik, DJ ;
Daly, NL ;
Bond, T ;
Waine, C .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 294 (05) :1327-1336
[68]   Structures of naturally occurring circular proteins from bacteria [J].
Craik, DJ ;
Daly, NL ;
Saska, I ;
Trabi, M ;
Rosengren, KJ .
JOURNAL OF BACTERIOLOGY, 2003, 185 (14) :4011-4021
[69]   Genetics and assembly line enzymology of siderophore biosynthesis in bacteria [J].
Crosa, JH ;
Walsh, CT .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (02) :223-+
[70]   Studies of the interaction of potassium(I), calcium(II), magnesium(II), and copper(II) with cyclosporin A [J].
Cusack, RM ;
Grondahl, L ;
Fairlie, DP ;
Hanson, GR ;
Gahan, LR .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 97 (02) :191-198
234567891011