Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

被引：210

作者：

McIntosh, John A. ^{[1
]}

Donia, Mohamed S. ^{[1
]}

Schmidt, Eric W. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 04期

关键词：

BIOSYNTHETIC GENE-CLUSTER; STAPHYLOCOCCUS-AUREUS VIRULENCE; PROMOTES SECONDARY METABOLISM; ASSEMBLY-LINE ENZYMOLOGY; AMINO-ACID SUBSTITUTIONS; STREPTOCOCCUS-MUTANS T8; LANTIBIOTIC MUTACIN II; SBO-ALB LOCUS; BACILLUS-SUBTILIS; POSTTRANSLATIONAL MODIFICATION;

D O I：

10.1039/b714132g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosomally synthesized bacterial natural products rival the nonribosomal peptides in their structural and functional diversity. The last decade has seen substantial progress in the identification and characterization of biosynthetic pathways leading to ribosomal peptide natural products with new and unusual structural motifs. In some of these cases, the motifs are similar to those found in nonribosomal peptides, and many are constructed by convergent or even paralogous enzymes. Here, we summarize the major structural and biosynthetic categories of ribosomally synthesized bacterial natural products and, where applicable, compare them to their homologs from nonribosomal biosynthesis.

引用

页码：537 / 559

页数：23

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