Paraneoplastic neurological syndromes

被引：110

作者：

Leypoldt, F. ^{[1
,4
]}

Wandinger, K. -P. ^{[2
,3
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, D-20246 Hamburg, Germany

[2] Univ Hosp Schleswig Holstein, Inst Clin Chem, Lubeck, Germany

[3] Univ Hosp Schleswig Holstein, Dept Neurol, Lubeck, Germany

[4] August Pi I Sunyer Biomed Res Inst IDIBAPS, Catalan Inst Res & Adv Studies ICREA, Josep Dalmaus Lab, Barcelona, Spain

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2014年 / 175卷 / 03期

关键词：

anti-NMDA receptor encephalitis; limbic encephalitis; paraneoplastic antibodies; paraneoplastic syndromes; CELL LUNG-CANCER; OPSOCLONUS-MYOCLONUS SYNDROME; NMDA-RECEPTOR ENCEPHALITIS; EATON MYASTHENIC SYNDROME; LIMBIC ENCEPHALITIS; PROGRESSIVE ENCEPHALOMYELITIS; CEREBELLAR DEGENERATION; CLINICAL ANALYSIS; PERIPHERAL-NERVE; MORVANS SYNDROME;

D O I：

10.1111/cei.12185

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific interest. Knowledge of these subgroups and their associated autoantibodies is important in therapeutic decision-making. However, the abundance of new autoantibodies and syndromes can be confusing. This review paper summarizes current knowledge and new developments in the field of paraneoplastic neurological syndromes, their classification, pathophysiology and treatment.

引用

页码：336 / 348

页数：13

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