Investigating the effects of walnut ointment on non-healing burn wounds

被引：7
作者：
Chen, Qian [1 ,2 ]
Deng, Xingwang [1 ,3 ]
Qiang, Lijuan [1 ,4 ]
Yao, Ming [5 ]
Guan, Lifeng [5 ]
Xie, Nan [6 ]
Zhao, Dan [7 ,8 ]
Ma, Jiaxiang [7 ,8 ]
Ma, Liqiong [9 ]
Wu, Yinsheng [5 ]
Xie, Yan [7 ,8 ,10 ]
机构：
[1] Ningxia Med Univ, Sch Clin Med, Yinchuan, Ningxia, Peoples R China
[2] Xinyang Cent Hosp, Dept Burns & Plast Surg, Xinyang, Henan, Peoples R China
[3] First Peoples Hosp Shizuishan, Dept Burns & Plast Surg, Shizuishan, Ningxia, Peoples R China
[4] Peoples Hosp Ningxia Hui Autonomous Reg, Dept Burns & Plast Surg, Yinchuan, Ningxia, Peoples R China
[5] Gen Hosp Ningxia Med Univ, Dept Burns & Plast Surg, Yinchuan, Ningxia, Peoples R China
[6] Beijing Natl Hlth Hosp, Clin Med Res Ctr, Natl Hlth Commiss, Beijing, Peoples R China
[7] Gen Hosp Ningxia Med Univ, Tissue Organ Bank, 804 Shengli St, Yinchuan 750004, Ningxia, Peoples R China
[8] Gen Hosp Ningxia Med Univ, Tissue Engn Ctr, 804 Shengli St, Yinchuan 750004, Ningxia, Peoples R China
[9] Ningxia Med Univ, Dept Pathol, Gen Hosp, Yinchuan, Ningxia, Peoples R China
[10] Queensland Univ Technol, Sch Biomed Sci, Fac Hlth, Brisbane, Qld, Australia
来源：
BURNS | 2021年 / 47卷 / 02期
关键词：
Walnut ointment; Non-healing burn wounds; Wound healing; Porcine; Full-thickness burn wound models; FULL-THICKNESS BURN; PORCINE MODEL; SKIN; JUGLANS; THERAPY; BIOFILM; HEALTH; CELLS; RATS;
D O I：
10.1016/j.burns.2020.06.032
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Effective treatments for non-healing burn wounds are an unmet need for 95% of burn sufferers. Approaches currently available to treat non-healing burn wounds are not satisfactory due to undesirable side-effects or expense. The anti-oxidation and antibacterial activities of walnuts are recommended for treating chronic diseases. Walnut ointment has been developed and successfully applied to treat non-healing burn wounds in our hospital for decades. We report herein a detailed retrospective case review examining patients' response to the walnut ointment. The walnut ointment has shortened healing time of non healing burn wounds and improved clinical outcomes. In order to investigate the mechanism of action, walnut ointment has been applied on wounds of porcine full-thickness burn wound models. Histological and immunohistochemical analysis indicated our walnut ointment supports wound healing through promoting keratinocyte proliferation and differentiation. Taken together, we recommend the walnut ointment offers an effective and economical treatment for patients presenting with non-healing burn wounds. (c) 2020 Elsevier Ltd and ISBI. All rights reserved.
引用
收藏
页码：455 / 465
页数：11
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