Extracellular vesicles in cancer nanomedicine

被引：86

作者：

Tarasov, Vadim V. ^{[1
]}

Svistunov, Andrey A. ^{[1
]}

Chubarev, Vladimir N. ^{[1
]}

Dostdar, Samira A. ^{[1
]}

Sokolov, Alexander V. ^{[1
]}

Brzecka, Anna ^{[2
]}

Sukocheva, Olga ^{[3
]}

Neganova, Margarita E. ^{[4
]}

Klochkov, Sergey G. ^{[4
]}

Somasundaram, Siva G. ^{[5
]}

Kirkland, Cecil E. ^{[5
]}

Aliev, Gjumrakch ^{[1
,4
,6
]}

机构：

[1] Sechenov Univ, Sechenov First Moscow State Med Univ, 8-2 Trubetskaya St, Moscow 119991, Russia

[2] Wroclaw Med Univ, Dept Pulmonol & Lung Canc, Wroclaw, Poland

[3] Flinders Univ S Australia, Coll Nursing & Hlth Sci, Bedford Pk, SA, Australia

[4] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Russia

[5] Salem Univ, Dept Biol Sci, Salem, WV USA

[6] GALLY Int Res Inst, 7733 Louis Pasteur Dr,330, San Antonio, TX 78229 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2021年 / 69卷

关键词：

Cancer; Exosomes; Nanodrug delivery; Vaccines; Extracellular vesicles;

D O I：

10.1016/j.semcancer.2019.08.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.

引用

页码：212 / 225

页数：14

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