Synthesis and Self-Assembly of Biodegradable Poly(ethylene oxide)-b-Polycaprolactone (PEO-b-PCL) Diblock Copolymers

被引：0
作者：
Li, G. [1 ,2 ]
Ghoroghchian, P. [3 ,4 ]
Qi, W. [2 ]
Christian, N. [3 ,4 ]
Frail, P. R. [2 ]
Hammer, D. A. [3 ,4 ]
Therien, M. J. [2 ]
机构：
[1] Carestream Hlth Inc, 1999 Lake Ave, Rochester, NY 14650 USA
[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
[3] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
[4] Univ Penn, Sch Engn & Appl Sci, Philadelphia, PA 19104 USA
来源：
NSTI NANOTECH 2008, VOL 2, TECHNICAL PROCEEDINGS: LIFE SCIENCES, MEDICINE, AND BIO MATERIALS | 2008年
关键词：
nanostructured polymersomes; synthesis; self-assembly; poly(ethylene oxide)-b-polycaprolactone (PEO-b-PCL) diblock copolymers; biodegradable;
D O I：
暂无
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A series of amphiphilic poly(ethylene oxide)-b-polycaprolactone (PEO-b-PCL) diblock copolymers had been synthesized by ring-opening or sequential anionic living polymerization. Nuclear Magnetic Resonance (NMR) and gel permeation chromatography (GPQ were used to characterize these copolymers. All copolymers have polydispersity index (PDI) from 1.14 to 1.37 by GPC. Two self-assembly techniques, film rehydration and organic solvent extraction, had been employed to process polymersomes. The perfect nanostructured polymersomes were processed by freeze-thaw-sonication film rehydration technique. The polymersomes with sizes from a hundred nanometer to several microns were obtained from these copolymers. Polymersomes could only be made from the copolymers with PEO blocks (Mn: 2k-3.8k) and GEO (11.8-18.8%). Film rehydration is a highly favorable self-assembly method for preparing biodegradable nanostructured polymersomes.
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收藏
页码：661 / +
页数：2
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