A common reference-based indirect comparison meta-analysis of eslicarbazepine versus lacosamide as add on treatments for focal epilepsy

被引:13
作者
Brigo, Francesco [1 ,2 ]
Trinka, Eugen [3 ,4 ,5 ]
Bragazzi, Nicola Luigi [6 ,7 ]
Nardone, Raffaele [2 ,3 ]
Milan, Alberto [8 ]
Grillo, Elisabetta [8 ]
机构
[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Piazzale LA Scuro 10, I-37134 Verona, Italy
[2] Franz Tappeiner Hosp, Dept Neurol, Merano, Italy
[3] Paracelsus Med Univ, Christian Doppler Klin, Dept Neurol, Salzburg, Austria
[4] Ctr Cognit Neurosci, Salzburg, Austria
[5] UMIT Univ Hlth Sci Med Informat & Technol, Dept Publ Hlth Technol Assessment, Hall In Tirol, Austria
[6] Univ Genoa, Sch Publ Hlth, Dept Hlth Sci, DISSAL, Genoa, Italy
[7] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Matern, DINOGMI, Sect Psychiat, Genoa, Italy
[8] Med Dept Eisai srl, San Donato Milanese, Italy
关键词
Efficacy; Eslicarbazepine acetate; Focal epilepsy; Indirect comparison meta-analysis; Lacosamide; PARTIAL-ONSET SEIZURES; REFRACTORY PARTIAL EPILEPSY; ANTIEPILEPTIC DRUGS; ADJUNCTIVE THERAPY; DOUBLE-BLIND; EFFICACY; ACETATE; SAFETY; TOLERABILITY; ADULTS;
D O I
10.1016/j.eplepsyres.2016.08.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Eslicarbazepine acetate (ESL) and lacosamide (LCM) have recently emerged as add-on treatments in patients with focal epilepsy experiencing seizures despite adequate monotherapy. Both drugs enhance slow inactivation of voltage-gated sodium channels. To date no randomized controlled trial (RCT) has directly compared ESL with LCM as add-on treatments for focal epilepsy. Our aim was to indirectly compare the efficacy of ESL and LCM used as add-on treatments in patients with focal epilepsy using common reference-based indirect comparison meta-analysis. Methods: We systematically searched RCTs in which ESL or LCM has been used as add-on treatment in patients with focal epilepsy and compared with placebo. Following outcomes were considered: >= 50% reduction in seizure frequency; seizure freedom; treatment withdrawal for any reason; >= 25% increase in seizure frequency. Random-effects Mantel-Haenszel meta-analyses were performed to obtain odds ratios (ORs) for the efficacy of ESL or LCM versus placebo. Adjusted indirect comparisons were then made between ESL and LCM using the obtained results, and comparing the minimum and the highest effective recommended daily dose of each drug. Results: Eight studies were included. Indirect comparisons adjusted for dose-effect showed no difference between ESL and LCM for responder rate, seizure freedom, and withdrawal rates. We could not assess increase in seizure frequency due to lack of data. Conclusions: Indirect comparisons failed to find a significant difference in efficacy between add-on ESL and LCM in patients with focal epilepsy. Direct head-to-head clinical trials comparing ESL with LCM as add-on antiepileptic treatment are required to confirm these results. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:12 / 18
页数:7
相关论文
共 42 条
[1]   Eslicarbazepine acetate (BIA 2-093) [J].
Almeida, Luis ;
Soares-da-Silva, Patricio .
NEUROTHERAPEUTICS, 2007, 4 (01) :88-96
[2]  
[Anonymous], ZEB ESL AC TABL SUMM
[3]  
[Anonymous], REP IND COMP WORK GR
[4]  
[Anonymous], 2016, Summary of product characteristics kadcyla (trastuzumab-emtansine)
[5]   Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy [J].
Ben-Menachem, E. ;
Gabbai, A. A. ;
Hufnagel, A. ;
Maia, J. ;
Almeida, L. ;
Soares-da-Silva, P. .
EPILEPSY RESEARCH, 2010, 89 (2-3) :278-285
[6]   Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures [J].
Ben-Menachem, Elinor ;
Biton, Victor ;
Jatuzis, Dalius ;
Abou-Khalil, Bassel ;
Doty, Pamela ;
Rudd, G. David .
EPILEPSIA, 2007, 48 (07) :1308-1317
[7]   Lacosamide:: A review of preclinical properties [J].
Beyreuther, Bettina K. ;
Freitag, Joachim ;
Heers, Cara ;
Krebsfaenger, Niels ;
Scharfenecker, Ute ;
Stoehr, Thomas .
CNS DRUG REVIEWS, 2007, 13 (01) :21-42
[8]   Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials [J].
Bodalia, Pritesh N. ;
Grosso, Anthony M. ;
Sofat, Reecha ;
MacAllister, Raymond J. ;
Smeeth, Liam ;
Dhillon, Soraya ;
Casas, Juan-Pablo ;
Wonderling, David ;
Hingorani, Aroon D. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 76 (05) :649-667
[9]   A Common Reference-Based Indirect Comparison Meta-Analysis of Buccal versus Intranasal Midazolam for Early Status Epilepticus [J].
Brigo, Francesco ;
Nardone, Raffaele ;
Tezzon, Frediano ;
Trinka, Eugen .
CNS DRUGS, 2015, 29 (09) :741-757
[10]   A common reference-based indirect comparison meta-analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus [J].
Brigo, Francesco ;
Igwe, Stanley C. ;
Nardone, Raffaele ;
Tezzon, Frediano ;
Bongiovanni, Luigi Giuseppe ;
Trinka, Eugen .
EPILEPTIC DISORDERS, 2013, 15 (03) :314-323