Non-linear effects in ruthenium-catalysed asymmetric hydrogenation with atropisomeric diphosphanes

被引：0
作者：
Girard, C
Genêt, JP
Bulliard, M
机构：
[1] Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, CNRS, UMR 7573, F-75231 Paris 05, France
[2] La Croix Cadeau, PPG Sipsy, F-49242 Avrille, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 1999卷 / 11期
关键词：
nonlinear effects; asymmetric catalysis; ruthenium complexes; atropisomeric phosphanes; hydrogenation;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A strong positive nonlinear effect (asymmetric amplification) was found to take place during asymmetric hydrogenations using chiral atropisomeric diphosphane-ruthenium catalysts. As an example, at atmospheric pressure the use of 50% ee BINAP to prepare [(binap)Ru(Br)(2)] give rise to a hydrogenated product with 91% ee. The influence of temperature and hydrogen pressure on this effect are presented. These nonlinear effects can be explained on the basis of a hydrogenation mechanism in which diastereomeric dimers as pre-catalytic species are present.
引用
收藏
页码：2937 / 2942
页数：6
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