Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

被引：21
作者：
Friedrich, Nele [1 ]
Krebs, Alexander [1 ]
Nauck, Matthias [1 ]
Wallaschofski, Henri [1 ]
机构：
[1] Univ Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2010年 / 48卷 / 01期
关键词：
Immulite; 2500; insulin-like growth factor I; insulin-like growth factor binding protein; quantile regression; references ranges; Study of Health in Pomerania (SHIP); REFERENCE VALUES; REFERENCE INTERVALS; IGFBP-3; LEVELS; SEX; CHILDHOOD; CHILDREN; ADOLESCENCE; DIAGNOSIS; SYSTEM; ADULTS;
D O I：
10.1515/CCLM.2010.009
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression. Methods: From the Study of Health in Pomerania (SHIP), 1798 men and women aged 25-85 years were recruited. Serum IGF-I and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 2500 (R) analyzer. Quantile regressions were performed to calculate the 2.5th and 97.5th percentiles. Results: The reference ranges identified 43 (4.6%) women and 41 (4.8%) men with serum IGF-I concentrations, and 47 (5.0%) women and 42 (5.0%) men with serum IGFBP-3 concentrations outside the reference range. Conclusions: The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3. Clin Chem Lab Med 2010; 48: 115-20.
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页码：115 / 120
页数：6
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