The mosaic that is our genome

被引：90

作者：

Pääbo, S ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany

来源：

NATURE | 2003年 / 421卷 / 6921期

关键词：

D O I：

10.1038/nature01400

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need to consider the genome as a mosaic of discrete segments, each with its own unique history and relatedness to different contemporary and ancestral individuals.

引用

页码：409 / 412

页数：4

共 42 条

[31] Alu insertion polymorphisms and human evolution: Evidence for a larger population size in Africa [J].

Stoneking, M ;

Fontius, JJ ;

Clifford, SL ;

Soodyall, H ;

Arcot, SS ;

Saha, N ;

Jenkins, T ;

Tahir, MA ;

Deininger, PL ;

Batzer, MA .

GENOME RESEARCH, 1997, 7 (11) :1061-1071

[32] Modern human origins: progress and prospects [J].

Stringer, C .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 357 (1420) :563-579

[33] Testing multiregionality of modern human origins [J].

Takahata, N ;

Lee, SH ;

Satta, Y .

MOLECULAR BIOLOGY AND EVOLUTION, 2001, 18 (02) :172-183

[34] Global patterns of linkage disequilibrium at the CD4 locus and modern human origins [J].

Tishkoff, SA ;

Dietzsch, E ;

Speed, W ;

Pakstis, AJ ;

Kidd, JR ;

Cheung, K ;

BonneTamir, B ;

SantachiaraBenerecetti, AS ;

Moral, P ;

Krings, M ;

Paabo, S ;

Watson, E ;

Risch, N ;

Jenkins, T ;

Kidd, KK .

SCIENCE, 1996, 271 (5254) :1380-1387

[35]

Tomasello M., 1997, PRIMATE COGNITION

[36] Y chromosome sequence variation and the history of human populations [J].

Underhill, PA ;

Shen, PD ;

Lin, AA ;

Jin, L ;

Passarino, G ;

Yang, WH ;

Kauffman, E ;

Bonné-Tamir, B ;

Bertranpetit, J ;

Francalacci, P ;

Ibrahim, M ;

Jenkins, T ;

Kidd, JR ;

Mehdi, SQ ;

Seielstad, MT ;

Wells, RS ;

Piazza, A ;

Davis, RW ;

Feldman, MW ;

Cavalli-Sforza, LL ;

Oefner, PJ .

NATURE GENETICS, 2000, 26 (03) :358-361

[37] AFRICAN POPULATIONS AND THE EVOLUTION OF HUMAN MITOCHONDRIAL-DNA [J].

VIGILANT, L ;

STONEKING, M ;

HARPENDING, H ;

HAWKES, K ;

WILSON, AC .

SCIENCE, 1991, 253 (5027) :1503-1507

[38] MOLECULAR STRUCTURE OF NUCLEIC ACIDS - A STRUCTURE FOR DEOXYRIBOSE NUCLEIC ACID [J].

WATSON, JD ;

CRICK, FHC .

NATURE, 1953, 171 (4356) :737-738

[39] Cultures in chimpanzees [J].

Whiten, A ;

Goodall, J ;

McGrew, WC ;

Nishida, T ;

Reynolds, V ;

Sugiyama, Y ;

Tutin, CEG ;

Wrangham, RW ;

Boesch, C .

NATURE, 1999, 399 (6737) :682-685

[40] A MOLECULAR TIME SCALE FOR HUMAN EVOLUTION [J].

WILSON, AC ;

SARICH, VM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 63 (04) :1088-&

← 1 2 3 4 5 →