The mosaic that is our genome

被引:90
作者
Pääbo, S [1 ]
机构
[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
关键词
D O I
10.1038/nature01400
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need to consider the genome as a mosaic of discrete segments, each with its own unique history and relatedness to different contemporary and ancestral individuals.
引用
收藏
页码:409 / 412
页数:4
相关论文
共 42 条
[1]  
[Anonymous], 2002, GENOME BIOL
[2]  
BOTSTEIN D, 1980, AM J HUM GENET, V32, P314
[3]   MITOCHONDRIAL-DNA AND HUMAN-EVOLUTION [J].
CANN, RL ;
STONEKING, M ;
WILSON, AC .
NATURE, 1987, 325 (6099) :31-36
[4]  
Cavalli-Sforza LL, 1993, HIST GEOGRAPHY HUMAN
[5]   Genomic divergence between human and chimpanzee estimated from large-scale alignments of genomic sequences [J].
Chen, FC ;
Vallender, EJ ;
Wang, H ;
Tzeng, CS ;
Li, WH .
JOURNAL OF HEREDITY, 2001, 92 (06) :481-489
[6]   High-resolution haplotype structure in the human genome [J].
Daly, MJ ;
Rioux, JD ;
Schaffner, SE ;
Hudson, TJ ;
Lander, ES .
NATURE GENETICS, 2001, 29 (02) :229-232
[7]   Evolution of a HOXB6 intergenic region within the great apes and humans [J].
Deinard, A ;
Kidd, K .
JOURNAL OF HUMAN EVOLUTION, 1999, 36 (06) :687-703
[8]   Recent duplication, domain accretion and the dynamic mutation of the human genome [J].
Eichler, EE .
TRENDS IN GENETICS, 2001, 17 (11) :661-669
[9]   Molecular evolution of FOXP2, a gene involved in speech and language [J].
Enard, W ;
Przeworski, M ;
Fisher, SE ;
Lai, CSL ;
Wiebe, V ;
Kitano, T ;
Monaco, AP ;
Pääbo, S .
NATURE, 2002, 418 (6900) :869-872
[10]   Intra- and interspecific variation in primate gene expression patterns [J].
Enard, W ;
Khaitovich, P ;
Klose, J ;
Zöllner, S ;
Heissig, F ;
Giavalisco, P ;
Nieselt-Struwe, K ;
Muchmore, E ;
Varki, A ;
Ravid, R ;
Doxiadis, GM ;
Bontrop, RE ;
Pääbo, S .
SCIENCE, 2002, 296 (5566) :340-343