Synthesis of bis-Schiff bases of isatins and their antiglycation activity

被引：167
|
作者：
Khan, Khalid Mohammed [1 ]
Khan, Momin [1 ]
Ali, Muhammad [1 ]
Taha, Muhammad [1 ]
Rasheed, Saima [1 ]
Perveen, Shahnaz [2 ]
Choudhary, M. Iqbal [1 ]
机构：
[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] PCSIR Labs Complex, Karachi 75280, Pakistan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 22期
关键词：
Isatins; Bis-Schiff bases; Antiglycation; AGEPs; ANTIMICROBIAL ACTIVITY; GLYCATION; DERIVATIVES; COMPLEXES;
D O I：
10.1016/j.bmc.2009.09.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 +/- 4.59 mu M), 20 (IC50 = 257.61 +/- 5.63 mu M), and 7 (IC50 = 291.14 +/- 2.53 mu M) showed an excellent antiglycation activity better than the standard (rutin, IC50 = 294.46 +/- 1.50 mu M). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7795 / 7801
页数：7
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