Inhibitory effects of lapachol derivatives on Epstein-Barr virus activation

被引：78

作者：

Sacau, EP

Estévez-Braun, A

Ravelo, AG

Ferro, EA

Tokuda, H

Mukainaka, T

Nishino, H

机构：

[1] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, E-38206 Tenerife, Spain

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan

[3] Univ Asuncion, Dept Fitoquim, Asuncion, Paraguay

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(02)00542-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：483 / 488

页数：6