Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

被引：110

作者：

Willot, Matthieu ^{[1
]}

Radtke, Lea ^{[1
]}

Koenning, Daniel ^{[1
]}

Froehlich, Roland ^{[2
]}

Gessner, Viktoria H. ^{[1
]}

Strohmann, Carsten ^{[1
]}

Christmann, Mathias ^{[1
]}

机构：

[1] TU Dortmund Univ, D-44227 Dortmund, Germany

[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期

关键词：

antitumor agents; natural products; rearrangements; terpenes; total synthesis; RING-CLOSING-METATHESIS; NATURAL-PRODUCTS; OXIDATION;

D O I：

10.1002/anie.200905032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catnip craze: Nepetalactone, the psychoactive ingredient of catmint, was selected as starting material for the first enantioselective synthesis of englerin A. This cytotoxic guaiane sesquiterpene is a highly selective inhibitor (1-87 nM) of several renal cancer cell lines. The absolute configuration of this natural product was determined by total synthesis. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9105 / 9108

页数：4

共 40 条

[1]

[Anonymous], 2006, ANGEW CHEM

[2]

[Anonymous], [No title captured]

[3] BIOSYNTHESIS OF TERPENES AND STEROIDS .5. SYNTHESIS OF ERGOSTA-5,7,22,24(28)-TETRAEN-3BETA-OL, A BIOSYNTHETIC PRECURSOR OF ERGOSTEROL [J].