Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

被引：12

作者：

Li, Tingting ^{[1
]}

Wei, Zheng ^{[1
]}

Sun, Yanping ^{[1
]}

Wang, Qiuhong ^{[2
]}

Kuang, Haixue ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, 24 Heping Rd, Harbin 150040, Heilongjiang, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, 280 Outer Ring Rd, Guangzhou 510006, Guangdong, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 14期

关键词：

psoriasis; withanolides; Datura metel L; imiquimod; inflammation; INFLAMMATION; EPIDEMIOLOGY; PATHOGENESIS; MICE;

D O I：

10.3390/molecules24142596

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from Datura metel L.; are the main effective components for the treatment of psoriasis. However, the precise mechanisms of action of withanolides for the treatment of psoriasis remain unclear. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. In addition, we also found that withanolides suppressed the activation of STAT3, ERK1/2 and P38 signaling pathways in IMQ-stimulated HaCat cells. These results suggest that withanolides possess an anti-inflammatory effect and have significant therapeutic potential for the prevention and treatment of psoriasis.

引用

页数：15

共 30 条

[1] The Effect of Folate Supplementation on Methotrexate Efficacy and Toxicity in Psoriasis Patients and Folic Acid Use by Dermatologists in the USA [J].

Al-Dabagh, Amir ;

Davis, Scott A. ;

Kinney, Megan A. ;

Huang, Karen ;

Feldman, Steven R. .

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2013, 14 (03) :155-161

[2]

Beutner Karl R., 1997, American Journal of Medicine, V102, P9

[3] Etiology and Pathogenesis of Psoriasis [J].

Boehncke, Wolf-Henning .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2015, 41 (04) :665-+

[4] Scanning the Immunopathogenesis of Psoriasis [J].

Chiricozzi, Andrea ;

Romanelli, Paolo ;

Volpe, Elisabetta ;

Borsellino, Giovanna ;

Romanelli, Marco .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (01)

[5] Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions [J].

Davidovici, Batya B. ;

Sattar, Naveed ;

Joerg, Prinz C. ;

Puig, Luis ;

Emery, Paul ;

Barker, Jonathan N. ;

van de Kerkhof, Peter ;

Stahle, Mona ;

Nestle, Frank O. ;

Girolomoni, Giampiero ;

Krueger, James G. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (07) :1785-1796

[6] Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium [J].

Habtemariam, S .

PLANTA MEDICA, 1997, 63 (01) :15-17

[7] Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves [J].

Jayaprakasam, B ;

Zhang, YJ ;

Seeram, NP ;

Nair, MG .

LIFE SCIENCES, 2003, 74 (01) :125-132

[8] Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions [J].

Jia, Hai-Yan ;

Shi, Ying ;

Luo, Long-Fei ;

Jiang, Guan ;

Zhou, Qiong ;

Xu, Shi-Zheng ;

Lei, Tie-Chi .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 37 (02) :359-368

[9] Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer [J].

Jurikova, Miroslava ;

Danihel, Ludovit ;

Polak, Stefan ;

Varga, Ivan .

ACTA HISTOCHEMICA, 2016, 118 (05) :544-552

[10] The Immunopathogenesis of Psoriasis [J].

Kim, Jaehwan ;

Krueger, James G. .

DERMATOLOGIC CLINICS, 2015, 33 (01) :13-+

← 1 2 3 →