Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease

被引：22
作者：
Fernandes, Karla S. S. [1 ]
Brum, Doralina Guimaraes [2 ]
Sandrim, Valeria Cristina [1 ]
Guerreiro, Carlos Tostes [3 ]
Barreira, Amilton Antunes [2 ]
Tanus-Santos, Jose Eduardo [1 ]
机构：
[1] Univ Sao Paulo, Dept Pharmacol Med & Rehabil Locomotor Apparat, Med Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Dept Neurosci & Behav Med & Rehabil Locomotor App, Med Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Dept Biomech Med & Rehabil Locomotor Apparat, Med Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 214卷 / 1-2期
关键词：
Multiple sclerosis; Haplotypes; Matrix metalloproteinase-9; Polymorphism; EDSS; Pharmacogenetics; MMP-9 MICROSATELLITE POLYMORPHISM; ABDOMINAL AORTIC-ANEURYSM; CORONARY-ARTERY-DISEASE; GELATINASE B GENE; INTERFERON-BETA; MATRIX METALLOPROTEINASES; FUNCTIONAL POLYMORPHISM; CEREBROSPINAL-FLUID; PROMOTER; SUSCEPTIBILITY;
D O I：
10.1016/j.jneuroim.2009.07.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is an autoimmune disease causing severe neurological disability. This study was carried out in order to determine whether the MMP-9 C-1562T and (CA)(13-25) polymorphisms are associated with MS. A total of 165 patients (92 whites/73 mulattos) and 191 controls (96 whites/95 mulattos) were enrolled in the study. While no difference in C-1562T polymorphism was observed between MS and healthy subjects, (CA)(n) genotypes and alleles were associated with MS. Moreover, the haplotypes are not associated with MS but seem to be relevant to the clinical status of MS. Thus the (CA)(n) polymorphism may contribute to MS susceptibility, but C-1562T and (CA)(n) haplotypes may modulate disease severity. (c) 2009 Elsevier B.V. All rights reserved.
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收藏
页码：128 / 131
页数：4
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