Activated macrophages in the tumour microenvironment - dancing to the tune of TLR and NF-κB

被引：44
作者：
Hallam, Simon [1 ]
Escorcio-Correia, Monica [1 ]
Soper, Robin [1 ]
Schultheiss, Anne [1 ]
Hagemann, Thorsten [1 ]
机构：
[1] Queen Mary Univ London, Inst Canc, Ctr Canc & Inflammat, Barts & London Sch Med & Dent, London EC1M 6BQ, England
来源：
JOURNAL OF PATHOLOGY | 2009年 / 219卷 / 02期
基金：
英国医学研究理事会;
关键词：
macrophage; neoplasia; tumour microenvironment; Toll like receptors; NF-kappa B; TOLL-LIKE RECEPTORS; IKK-BETA; INTESTINAL MACROPHAGES; INFLAMMATORY RESPONSES; IMMUNE DYSFUNCTION; GENE-EXPRESSION; NECROSIS-FACTOR; MYELOID CELLS; CANCER-CELLS; TNF-ALPHA;
D O I：
10.1002/path.2602
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A large number of variables have been identified which appear to influence macrophage phenotype within the tumour microenvironment. These include reciprocal chemical and physical interactions with tumour cells and with non-malignant cells of the tumour microenvironment, tissue oxygen tension, and the origin and prior experience of the particular macrophage population. In this review we outline the key evidence for these influences and consider how macrophage phenotype is acquired and the relevance of the TLR-NF-kappa B pathway. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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收藏
页码：143 / 152
页数：10
相关论文
共 85 条
[1]   Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies [J].
Apetoh, Lionel ;
Tesniere, Antoine ;
Ghiringhelli, Francois ;
Kroemer, Guido ;
Zitvogel, Laurence .
CANCER RESEARCH, 2008, 68 (11) :4026-4030
[2]   Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].
Apetoh, Lionel ;
Ghiringhelli, Francois ;
Tesniere, Antoine ;
Obeid, Michel ;
Ortiz, Carla ;
Criollo, Alfredo ;
Mignot, Gregoire ;
Maiuri, M. Chiara ;
Ullrich, Evelyn ;
Saulnier, Patrick ;
Yang, Huan ;
Amigorena, Sebastian ;
Ryffel, Bernard ;
Barrat, Franck J. ;
Saftig, Paul ;
Levi, Francis ;
Lidereau, Rosette ;
Nogues, Catherine ;
Mira, Jean-Paul ;
Chompret, Agnes ;
Joulin, Virginie ;
Clavel-Chapelon, Francoise ;
Bourhis, Jean ;
Andre, Fabrice ;
Delaloge, Suzette ;
Tursz, Thomas ;
Kroemer, Guido ;
Zitvogel, Laurence .
NATURE MEDICINE, 2007, 13 (09) :1050-1059
[3]   Inflammation and cancer: back to Virchow? [J].
Balkwill, F ;
Mantovani, A .
LANCET, 2001, 357 (9255) :539-545
[4]   Cancer - An inflammatory link [J].
Balkwill, F ;
Coussens, LM .
NATURE, 2004, 431 (7007) :405-406
[5]  
BALKWILL F, 2009, NAT REV CAN IN PRESS
[6]   BCG (Bacillus of Calmette Guerin) therapy of high-risk superficial bladder cancer [J].
Bassi, PF .
SURGICAL ONCOLOGY-OXFORD, 2002, 11 (1-2) :77-83
[7]   Role of primary intrahepatic T-cell activation in the 'liver tolerance effect' [J].
Bertolino, P ;
McCaughan, GW ;
Bowen, DG .
IMMUNOLOGY AND CELL BIOLOGY, 2002, 80 (01) :84-92
[8]   High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity [J].
Bianchi, Marco E. ;
Manfredi, Angelo A. .
IMMUNOLOGICAL REVIEWS, 2007, 220 :35-46
[9]   The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies [J].
Bingle, L ;
Brown, NJ ;
Lewis, CE .
JOURNAL OF PATHOLOGY, 2002, 196 (03) :254-265
[10]   Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms [J].
Biswas, Subhra K. ;
Sica, Antonio ;
Lewis, Claire E. .
JOURNAL OF IMMUNOLOGY, 2008, 180 (04) :2011-2017
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