RP-HPLC Method for Estimation of Flucloxacillin Magnesium and Sodium Benzoate in Oral Suspension

被引：0

作者：

Sankar, D. Gowri ^{[1
]}

Rajeswari, A. ^{[1
]}

Babu, A. Nagesh ^{[1
]}

Krishna, M. Vamsi ^{[1
]}

机构：

[1] Andhra Univ, Dept Pharmaceut Anal & Qual Assurance, Univ Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 08期

关键词：

Flucloxacillin magnesium; Sodium benzoate; RP-HPLC; Oral Suspension;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, sensitive and precise reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of flucloxacillin magnesium and sodium benzoate (preservative) in oral suspension. The quantification was carried out using a Kromasil 100, C-18 column, 150 mm x 4.6 mm i.d. and 5 mu m particle size in gradient mode with mobile phase comprising pH 5.0 phosphate buffer and acetonitrile at a flow rate of 1.5 mL/min. The eluent was monitered at 225 nm. The retention time of the drug was 10.9 min and of the sodium benzoate (preservative) was 2.02 min. The calibration curve was linear in the concentration range of 10-150 mu g/mL. The proposed method was statistically evaluated and can be applied for routine quality control analysis of flucloxacillin magnesium and sodium benzoate in oral suspension.

引用

页码：5843 / 5846

页数：4

共 4 条

[1]

CHEN Y, 2004, ZHONG GUO KANGSHENGS, V29, P15

[2] An isocratic ion exchange HPLC method for the simultaneous determination of flucloxacillin and amoxicillin in a pharmaceutical formulation for injection [J].