Non-Hodgkin Lymphoma Following Temozolomide

被引：11
|
作者：
Sharma, Atul [1 ]
Gupta, Deepak [1 ]
Mohanti, B. K. [2 ]
Thulkar, Sanjay [3 ]
Dwary, Amit [1 ]
Goyal, Shikha [2 ]
Muzumder, Sandeep [2 ]
Das, Prasenjit [4 ]
机构：
[1] All India Inst Med Sci, Dr BRA IRCH, Dept Med Oncol, New Delhi 110029, India
[2] All India Inst Med Sci, Dr BRA IRCH, Dept Radiat Oncol, New Delhi 110029, India
[3] All India Inst Med Sci, Dr BRA IRCH, Dept Radiodiag, New Delhi 110029, India
[4] All India Inst Med Sci, Dr BRA IRCH, Dept Pathol, New Delhi 110029, India
来源：
PEDIATRIC BLOOD & CANCER | 2009年 / 53卷 / 04期
关键词：
glioblastoma multiforme; temozolomide; second malignancy; non-Hodgkin lymphoma;
D O I：
10.1002/pbc.22090
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Temozolomide (TMZ) is an oral alkylating agent with significant activity against glioblastoma multiforme (GBM) and melanoma. It increases survival by 2.5 months when used in combination with radiotherapy as an adjuvant therapy in GBM. Secondary MDS/AML or non-Hodgkin lymphoma attributed to TMZ exposure has been reported. We report a case of non-Hodgkin lymphoma secondary to temozolomide in a 20-year-old female who was treated for GBM with concurrent TMZ and radiotherapy. She developed lymphoma 2 months after completing chemoradiotherapy. Although she was treated with combination chemotherapy for lymphoma, she died of progressive GBM. Pediatr Blood Cancer 2009;53: 661-662. (C) 2009 Wiley-Lis, Inc.
引用
收藏
页码：661 / 662
页数：2
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