Aptasensor for lead(II) based on the use of a quartz crystal microbalance modified with gold nanoparticles

被引：38

作者：

Yuan, Min ^{[1
,2
]}

Song, Zhihong ^{[1
]}

Fei, Jiayu ^{[1
]}

Wang, Xinglong ^{[1
]}

Xu, Fei ^{[1
]}

Cao, Hui ^{[1
]}

Yu, Jinsong ^{[1
]}

机构：

[1] Univ Shanghai Sci & Technol, Inst Food Qual & Safety, Shanghai 200093, Peoples R China

[2] Univ Shanghai Sci & Technol, Shanghai Engn Res Ctr Food Microbiol, Shanghai 200093, Peoples R China

来源：

MICROCHIMICA ACTA | 2017年 / 184卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Determination of lead ion; Aptamer; Piezoelectric biosensor; Gold nanoparticles; Signal amplification; SELECTIVE DETECTION; BIOSENSOR; SENSOR; AMPLIFICATION; SPECTROMETRY; SENSITIVITY; CADMIUM; CARBON; ASSAY; PB2+;

D O I：

10.1007/s00604-017-2135-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The authors describe a quartz crystal microbalance based aptasensor for the determination of Pb2+. In order to enhance its response, oligonucleotide-embellished gold nanoparticles (AuNPs) were used to amplify the frequency changes. The method is based on the use of specific aptamers immobilized on the surface of the quartz crystal microbalance (QCM) and the binding of Pb2+, which prevents the self-assembly of the AuNPs on the QCM. Trace concentrations of Pb2+ can be determined by monitoring the change in the response frequency of the QCM. The method has a 4 nmola (TM) L-1 detection limit and works in the 5 to 200 nmola (TM) L-1 Pb2+ concentration range. This aptasensor also shows adequate selectivity for Pb2+ over potentially interfering metal ions.

引用

页码：1397 / 1403

页数：7

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