Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro

被引：22
作者：
Chia, Yi-Chen
Chang, Fang-Rong
Wu, Chin-Chung
Teng, Che-Ming
Chen, Keh-Shaw [1 ]
Wu, Yang-Chang
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Tajen Inst Technol, Dept Food Sci & Technol, Pingtung, Taiwan
[3] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 10764, Taiwan
来源：
PLANTA MEDICA | 2006年 / 72卷 / 13期
关键词：
D O I：
10.1055/s-2006-947196
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)-N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.
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收藏
页码：1238 / 1241
页数：4
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