Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro

被引：22

作者：

Chia, Yi-Chen

Chang, Fang-Rong

Wu, Chin-Chung

Teng, Che-Ming

Chen, Keh-Shaw ^{[1
]}

Wu, Yang-Chang

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Tajen Inst Technol, Dept Food Sci & Technol, Pingtung, Taiwan

[3] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 10764, Taiwan

来源：

PLANTA MEDICA | 2006年 / 72卷 / 13期

关键词：

D O I：

10.1055/s-2006-947196

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)-N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.

引用

页码：1238 / 1241

页数：4

共 26 条

[1]

AWE W, 1944, ARCH PHARMAZ BER DTS, V282, P97

[2] Antiplatelet and vasorelaxing actions of some aporphinoids [J].