Rapid Progression of Pleural Disease Due to Exposure to Libby Amphibole: "Not Your Grandfather's Asbestos Related Disease"

被引：24

作者：

Black, Bradford ^{[1
]}

Szeinuk, Jaime ^{[2
]}

Whitehouse, Alan C. ^{[1
]}

Levin, Stephen M. ^{[3
]}

Henschke, Claudia I. ^{[4
]}

Yankelevitz, David F. ^{[4
]}

Flores, Raja M. ^{[2
]}

机构：

[1] Ctr Asbestos Related Dis, Libby, MT USA

[2] Icahn Sch Med Mt Sinai, Dept Thorac Surg, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2014年 / 57卷 / 11期

关键词：

Libby amphibole; asbestosis; pleural disease; pulmonary function; disease progression; LUNG-FUNCTION; PULMONARY-FUNCTION; VERMICULITE; POPULATION; STANDARDIZATION; ABNORMALITIES; COMMUNITY; SYMPTOMS; MONTANA; PLAQUES;

D O I：

10.1002/ajim.22330

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

BackgroundResidents and mine employees from Libby, Montana, have been exposed to asbestiform amphiboles from the vermiculite mine that operated in this location from the mid-1920s until 1990. Clinical observations show a different form of asbestos-related toxicity than other forms of asbestos. MethodsFive illustrative cases from the Center for Asbestos-Related Diseases in Libby were selected. All had clear exposure histories, multiple follow-up visits, illustrative chest radiographic studies, serial pulmonary function tests, and sufficient length of follow-up to characterize disease progression. ResultsThese cases developed increasing symptoms of dyspnea and chest pain, progressive radiological changes that were predominantly pleural, and a restrictive pattern of impaired spirometry that rapidly progressed with significant loss of pulmonary function. ConclusionsLA exposure can cause a non-malignant pleural disease that is more rapidly progressive and more severe than the usual asbestos-related disease. Am. J. Ind. Med. 57:1197-1206, 2014. (c) 2014 Wiley Periodicals, Inc.

引用

页码：1197 / 1206

页数：10

共 38 条

[1] Pleuroparenchymal lung disease secondary to nonoccupational exposure to vermiculite [J].