A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-α][1,3,5]triazine-8-carbonitriles

被引：24
|
作者：
Lim, Felicia Phei Lin [1 ]
Luna, Giuseppe [2 ]
Dolzhenko, Anton V. [1 ,2 ]
机构：
[1] Monash Univ Malaysia, Sch Pharm, Selangor Darul Ehsan 47500, Malaysia
[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Pharm, Perth, WA 6845, Australia
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 50期
关键词：
Triazine; Pyrazole; Purine isostere; Multicomponent reaction; Microwave irradiation; A(2A) RECEPTOR ANTAGONISTS; PROTEIN-COUPLED RECEPTOR; FUNCTIONAL EXPRESSION; ADENINE RECEPTORS; DESIGN; INHIBITORS; MOUSE;
D O I：
10.1016/j.tetlet.2015.11.006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of novel 7-amino-substituted pyrazolo[1,5-alpha][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7016 / 7019
页数：4
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