A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-α][1,3,5]triazine-8-carbonitriles

被引：25

作者：

Lim, Felicia Phei Lin ^{[1
]}

Luna, Giuseppe ^{[2
]}

Dolzhenko, Anton V. ^{[1
,2
]}

机构：

[1] Monash Univ Malaysia, Sch Pharm, Selangor Darul Ehsan 47500, Malaysia

[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Pharm, Perth, WA 6845, Australia

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 50期

关键词：

Triazine; Pyrazole; Purine isostere; Multicomponent reaction; Microwave irradiation; A(2A) RECEPTOR ANTAGONISTS; PROTEIN-COUPLED RECEPTOR; FUNCTIONAL EXPRESSION; ADENINE RECEPTORS; DESIGN; INHIBITORS; MOUSE;

D O I：

10.1016/j.tetlet.2015.11.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel 7-amino-substituted pyrazolo[1,5-alpha][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7016 / 7019

页数：4

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