Transplant genetics and genomics

被引：51

作者：

Yang, Joshua Y. C. ^{[1
]}

Sarwal, Minnie M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Transplant Surg, 513 Parnassus Ave, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS GENETICS | 2017年 / 18卷 / 05期

关键词：

VERSUS-HOST-DISEASE; ANTIBODY-MEDIATED REJECTION; CELL-FREE DNA; INFLUENCE ALLOGRAFT SURVIVAL; NON-HLA ANTIBODIES; KIDNEY-TRANSPLANTATION; OPERATIONAL TOLERANCE; WIDE ASSOCIATION; HIGH-THROUGHPUT; H-Y;

D O I：

10.1038/nrg.2017.12

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor-recipient interactions that lead to transplant tolerance or rejection. Genetic analysis in transplantation, when linked to demographic and clinical outcomes, has the potential to drive personalized medicine by enabling individualized risk stratification and immunosuppression through the identification of variants associated with immune-mediated complications, post-transplant disease or alterations in drug-metabolizing genes.

引用

页码：309 / 326

页数：18

共 215 条

[41] Expression of miR-142-5p in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Chronic Antibody-Mediated Rejection [J].

Danger, Richard ;

Paul, Chloe ;

Giral, Magali ;

Lavault, Amelie ;

Foucher, Yohann ;

Degauque, Nicolas ;

Pallier, Annaick ;

Durand, Maxim ;

Castagnet, Stephanie ;

Van Huyen, Jean-Paul Duong ;

Delahousse, Michel ;

Renaudin, Karine ;

Soulillou, Jean-Paul ;

Brouard, Sophie .

PLOS ONE, 2013, 8 (04)

[42] Transplantation Between Monozygotic Twins: How Identical Are They? [J].

Day, Elizabeth ;

Kearns, Patrick K. ;

Taylor, Craig J. ;

Bradley, J. Andrew .

TRANSPLANTATION, 2014, 98 (05) :485-489

[43] Noninvasive monitoring of infection and rejection after lung transplantation [J].

De Vlaminck, Iwijn ;

Martin, Lance ;

Kertesz, Michael ;

Patel, Kapil ;

Kowarsky, Mark ;

Strehl, Calvin ;

Cohen, Garrett ;

Luikart, Helen ;

Neff, Norma F. ;

Okamoto, Jennifer ;

Nicolls, Mark R. ;

Cornfield, David ;

Weill, David ;

Valantine, Hannah ;

Khush, Kiran K. ;

Quake, Stephen R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (43) :13336-13341

[44] Circulating Cell-Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection [J].

De Vlaminck, Iwijn ;

Valantine, Hannah A. ;

Snyder, Thomas M. ;

Strehl, Calvin ;

Cohen, Garrett ;

Luikart, Helen ;

Neff, Norma F. ;

Okamoto, Jennifer ;

Bernstein, Daniel ;

Weisshaar, Dana ;

Quake, Stephen R. ;

Khush, Kiran K. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (241)

[45] A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation [J].

Delville, Marianne ;

Sigdel, Tara K. ;

Wei, Changli ;

Li, Jing ;

Hsieh, Szu-Chuan ;

Fornoni, Alessia ;

Burke, George W. ;

Bruneval, Patrick ;

Naesens, Maarten ;

Jackson, Annette ;

Alachkar, Nada ;

Canaud, Guillaume ;

Legendre, Christophe ;

Anglicheau, Dany ;

Reiser, Jochen ;

Sarwal, Minnie M. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (256)

[46] Differentially Expressed Gene Transcripts Using RNA Sequencing from the Blood of Immunosuppressed Kidney Allograft Recipients [J].

Dorr, Casey ;

Wu, Baolin ;

Guan, Weihua ;

Muthusamy, Amutha ;

Sanghavi, Kinjal ;

Schladt, David P. ;

Maltzman, Jonathan S. ;

Scherer, Steven E. ;

Brott, Marcia J. ;

Matas, Arthur J. ;

Jacobson, Pamala A. ;

Oetting, William S. ;

Israni, Ajay K. .

PLOS ONE, 2015, 10 (05)

[47] Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes [J].

Dorr, Casey R. ;

Freedman, Barry I. ;

Hicks, Pamela J. ;

Brown, W. Mark ;

Russell, Gregory B. ;

Julian, Bruce A. ;

Pastan, Stephen O. ;

Gautreaux, Michael D. ;

Muthusamy, Amutha ;

Chinnakotla, Srinath ;

Hauptfeld, Vera ;

Bray, Robert A. ;

Kirk, Allan D. ;

Divers, Jasmin ;

Israni, Ajay K. .

PLOS ONE, 2016, 11 (04)

[48] Evaluation of the Therapeutic Potential of Bone Marrow-Derived Myeloid Suppressor Cell (MDSC) Adoptive Transfer in Mouse Models of Autoimmunity and Allograft Rejection [J].

Drujont, Lucile ;

Carretero-Iglesia, Laura ;

Bouchet-Delbos, Laurence ;

Beriou, Gaelle ;

Merieau, Emmanuel ;

Hill, Marcelo ;

Delneste, Yves ;

Cuturi, Maria Cristina ;

Louvet, Cedric .

PLOS ONE, 2014, 9 (06)

[49] An integrated encyclopedia of DNA elements in the human genome [J].

Dunham, Ian ;

Kundaje, Anshul ;

Aldred, Shelley F. ;

Collins, Patrick J. ;

Davis, CarrieA. ;

Doyle, Francis ;

Epstein, Charles B. ;

Frietze, Seth ;

Harrow, Jennifer ;

Kaul, Rajinder ;

Khatun, Jainab ;

Lajoie, Bryan R. ;

Landt, Stephen G. ;

Lee, Bum-Kyu ;

Pauli, Florencia ;

Rosenbloom, Kate R. ;

Sabo, Peter ;

Safi, Alexias ;

Sanyal, Amartya ;

Shoresh, Noam ;

Simon, Jeremy M. ;

Song, Lingyun ;

Trinklein, Nathan D. ;

Altshuler, Robert C. ;

Birney, Ewan ;

Brown, James B. ;

Cheng, Chao ;

Djebali, Sarah ;

Dong, Xianjun ;

Dunham, Ian ;

Ernst, Jason ;

Furey, Terrence S. ;

Gerstein, Mark ;

Giardine, Belinda ;

Greven, Melissa ;

Hardison, Ross C. ;

Harris, Robert S. ;

Herrero, Javier ;

Hoffman, Michael M. ;

Iyer, Sowmya ;

Kellis, Manolis ;

Khatun, Jainab ;

Kheradpour, Pouya ;

Kundaje, Anshul ;

Lassmann, Timo ;

Li, Qunhua ;

Lin, Xinying ;

Marinov, Georgi K. ;

Merkel, Angelika ;

Mortazavi, Ali .

NATURE, 2012, 489 (7414) :57-74

[50] High-throughput multiplex HLA genotyping by next-generation sequencing using multi-locus individual tagging [J].

Ehrenberg, Philip K. ;

Geretz, Aviva ;

Baldwin, Karen M. ;

Apps, Richard ;

Polonis, Victoria R. ;

Robb, Merlin L. ;

Kim, Jerome H. ;

Michael, Nelson L. ;

Thomas, Rasmi .

BMC GENOMICS, 2014, 15

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