Transplant genetics and genomics

被引：51

作者：

Yang, Joshua Y. C. ^{[1
]}

Sarwal, Minnie M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Transplant Surg, 513 Parnassus Ave, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS GENETICS | 2017年 / 18卷 / 05期

关键词：

VERSUS-HOST-DISEASE; ANTIBODY-MEDIATED REJECTION; CELL-FREE DNA; INFLUENCE ALLOGRAFT SURVIVAL; NON-HLA ANTIBODIES; KIDNEY-TRANSPLANTATION; OPERATIONAL TOLERANCE; WIDE ASSOCIATION; HIGH-THROUGHPUT; H-Y;

D O I：

10.1038/nrg.2017.12

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor-recipient interactions that lead to transplant tolerance or rejection. Genetic analysis in transplantation, when linked to demographic and clinical outcomes, has the potential to drive personalized medicine by enabling individualized risk stratification and immunosuppression through the identification of variants associated with immune-mediated complications, post-transplant disease or alterations in drug-metabolizing genes.

引用

页码：309 / 326

页数：18

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