Next-generation of selective histone deacetylase inhibitors

被引：104

作者：

Yang, Feifei ^{[1
,2
,3
]}

Zhao, Na ^{[1
]}

Ge, Di ^{[1
]}

Chen, Yihua ^{[2
,3
]}

机构：

[1] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China

[2] East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China

[3] East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China

来源：

RSC ADVANCES | 2019年 / 9卷 / 34期

基金：

中国国家自然科学基金;

关键词：

DIVERSITY-ORIENTED SYNTHESIS; BIOLOGICAL EVALUATION; HDAC INHIBITORS; CANCER-THERAPY; MOLECULAR-MECHANISMS; ISOFORM SELECTIVITY; EPIGENETIC THERAPY; ACID-DERIVATIVES; RATIONAL DESIGN; ACTIVITY ASSAY;

D O I：

10.1039/c9ra02985k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of cancers. First-generation inhibitors are mainly pan-HDACis that target multiple isoforms which might lead to serious side effects. At present, the next-generation HDACis are mainly focused on being class- or isoform-selective which can provide improved risk-benefit profiles compared to non-selective inhibitors. Because of the rapid development in next-generation HDACis, it is necessary to have an updated and state-of-the-art overview. Here, we summarize the strategies and achievements of the selective HDACis.

引用

页码：19571 / 19583

页数：13

共 137 条

[1] Epigenetic therapy in gastrointestinal cancer: the right combination [J].

Abdelfatah, Eihab ;

Kerner, Zachary ;

Nanda, Nainika ;

Ahuja, Nita .

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2016, 9 (04) :560-579

[2] The Role of HDAC6 in Cancer [J].

Aldana-Masangkay, Grace I. ;

Sakamoto, Kathleen M. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,

[3] Epigenetic protein families: a new frontier for drug discovery [J].

Arrowsmith, Cheryl H. ;

Bountra, Chas ;

Fish, Paul V. ;

Lee, Kevin ;

Schapira, Matthieu .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (05) :384-400

[4] Inhibition of HDAC6 Deacetylase Activity Increases Its Binding with Microtubules and Suppresses Microtubule Dynamic Instability in MCF-7 Cells [J].

Asthana, Jayant ;

Kapoor, Sonia ;

Mohan, Renu ;

Panda, Dulal .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (31) :22516-22526

[5] Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group [J].

Beckers, Thomas ;

Burkhardt, Carmen ;

Wieland, Heike ;

Gimmnich, Petra ;

Ciossek, Thomas ;

Maier, Thomas ;

Sanders, Karl .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (05) :1138-1148

[6] Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth [J].

Bergman, Joel A. ;

Woan, Karrune ;

Perez-Villarroel, Patricio ;

Villagra, Alejandro ;

Sotomayor, Eduardo M. ;

Kozikowski, Alan P. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (22) :9891-9899

[7] Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a] pyrazine and related heterocycles selective for the HDAC6 isoform [J].

Blackburn, Christopher ;

Barrett, Cynthia ;

Brunson, Mable ;

Chin, Janice ;

England, Dylan ;

Garcia, Kris ;

Gigstad, Kenneth ;

Gould, Alexandra ;

Gutierrez, Juan ;

Hoar, Kara ;

Rowland, R. Scott ;

Tsu, Christopher ;

Ringeling, John ;

Wager, Krista ;

Xu, He .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (23) :5450-5454

[8] Potent Histone Deacetylase Inhibitors Derived from 4-(Aminomethyl)-N-hydroxybenzamide with High Selectivity for the HDAC6 Isoform [J].

Blackburn, Christopher ;

Barrett, Cynthia ;

Chin, Janice ;

Garcia, Kris ;

Gigstad, Kenneth ;

Gould, Alexandra ;

Gutierrez, Juan ;

Harrison, Sean ;

Hoar, Kara ;

Lynch, Chrissie ;

Rowland, R. Scott ;

Tsu, Chris ;

Ringeling, John ;

Xu, He .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (18) :7201-7211

[9] Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights [J].

Bose, Prithviraj ;

Dai, Yun ;

Grant, Steven .

PHARMACOLOGY & THERAPEUTICS, 2014, 143 (03) :323-336

[10] Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain [J].

Bottomley, Matthew J. ;

Lo Surdo, Paola ;

Di Giovine, Paolo ;

Cirillo, Agostino ;

Scarpelli, Rita ;

Ferrigno, Federica ;

Jones, Philip ;

Neddermann, Petra ;

De Francesco, Raffaele ;

Steinkuhler, Christian ;

Gallinari, Paola ;

Carfi, Andrea .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (39) :26694-26704

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