Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

被引：141

作者：

Hassan, Kareem ^{[1
]}

Bhalla, Varun ^{[1
]}

El Regal, Mohammed Ezz ^{[1
]}

A-Kader, H. Hesham ^{[1
]}

机构：

[1] Univ Arizona, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Tucson, AZ 85724 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 34期

关键词：

Nonalcoholic fatty liver disease; Steatohepatitis; Nonalcoholic steatohepatitis; Pathogenesis; Treatments; Diagnosis; Management; Metformin; Vitamin E; Thiazolidinedione; Imaging; Prevalence; OBSTRUCTIVE SLEEP-APNEA; C-REACTIVE PROTEIN; RANDOMIZED CONTROLLED-TRIAL; HEPATIC INSULIN-RESISTANCE; TYPE-2; DIABETES-MELLITUS; LIFE-STYLE MODIFICATION; VITAMIN-E; GENE-EXPRESSION; ADIPOSE-TISSUE; NATURAL-HISTORY;

D O I：

10.3748/wjg.v20.i34.12082

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：12082 / 12101

页数：20

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