Self-Assembled Supramolecular Hetero-Bimetallacycles for Anticancer Potency by Intracellular Release

被引：42

作者：

Mishra, Anurag ^{[1
]}

Lee, Seung Chang ^{[1
]}

Kaushik, Neha ^{[2
]}

Cook, Timothy R. ^{[3
]}

Choi, Eun Ha ^{[2
]}

Kaushik, Nagendra Kumar ^{[2
]}

Stang, Peter J. ^{[3
]}

Chi, Ki-Whan ^{[1
]}

机构：

[1] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

[2] Kwangwoon Univ, Plasma Biosci Res Ctr, Seoul 139701, South Korea

[3] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 44期

基金：

新加坡国家研究基金会;

关键词：

antitumor agents; biological activity; ligands; metallacycles; self-assembly; supramolecular chemistry; DNA-BINDING; MOLECULAR RECOGNITION; INORGANIC-CHEMISTRY; SELECTIVE DETECTION; COORDINATION; RUTHENIUM; COMPLEXES; DESIGN; PLATINUM; SQUARE;

D O I：

10.1002/chem.201403372

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new tetracationic hetero-bimetallacycles, compounds 4 and 5, have been constructed from an N,N-bis(4-(pyridin-4-ylethynyl)phenyl)pyridine-2,6-dicarboxamide ligand (1), and cis-blocked complexes [M(dppf)(OTf)(2)] (dppf=1,1-bis(diphenylphosphino)ferrocene; OTf=trifluoromethanesulfonate; M=Pd (2), Pt (3)) in CH3NO2/CH2Cl2 (1:1) solvent. Both complexes were isolated with adequate yields as triflate salts and were then characterized using H-1, C-13, and (PNMR)-P-31 spectroscopy, elemental analysis, UV/Vis spectroscopy, and high-resolution electrospray mass spectrometry (HR-ESMS). The molecular structure of 4 was determined by molecular mechanics force-field calculations. The cytotoxic effect of both new complexes were analyzed against T98G (brain tumor), KB (head and neck cancer), SNU-80 (thyroid cancer), and HEK-293 non-malignant cell lines. The cytotoxicity of complexes 4 and 5 were found to be considerably more effective against cancer cells than reference drug cisplatin. Annexin-V/PI staining, caspase-3/7 activity, and the reduction in mitochondrial membrane potential justify a significant level of apoptosis in complex-treated cells.

引用

页码：14410 / 14420

页数：11

共 112 条

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