Despite convergent evidence indicating a variety of regional abnormalities of hemispheric asymmetry in schizophrenia, patterns of wider neural network asymmetry remain to be determined. In this study, we investigated alterations in hemispheric white matter topology in schizophrenia and their association with clinical manifestations of the illness. Weighted hemispheric brain anatomical networks were constructed for each of 116 right-handed patients with schizophrenia and 66 matched healthy participants. Graph theoretical approaches were then employed to estimate the hemispheric topological properties. We found that although small-world properties were preserved in the hemispheric network, a significant hemispheric-independent deficit of global integration was found in schizophrenia. Furthermore, a significant group-by-hemisphere interaction was revealed in the characteristic path length and global efficiency, attributing to significantly reduced hemispheric asymmetry of global integration in patients compared with healthy controls. Specifically, we found reduced asymmetric nodal efficiency in several frontal regions and the hippocampus. Finally, the abnormal hemispheric asymmetry of brain anatomical network topology was associated with clinical features (duration of illness and psychotic psychopathology) in patients. Our findings provide new insights into lateralized nature of hemispheric dysconnectivity and highlight the potential for using brain network measures of hemispheric asymmetry as neural biomarkers for schizophrenia and its clinical features.
机构:
Univ Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Yang, Cheng
Zhong, Suyu
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Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Zhong, Suyu
Zhou, Xiaolong
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Univ Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Zhou, Xiaolong
Wei, Long
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机构:
Univ Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Laiwu Vocat & Tech Coll, Laiwu, Shandong, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Wei, Long
Wang, Lijia
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Univ Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
Wang, Lijia
Nie, Shengdong
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Univ Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R ChinaUniv Shanghai Sci & Technol, Inst Med Imaging Engn, Sch Med Instrument & Food Engn, Shanghai, Peoples R China
机构:
Southern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Gen Hosp Cent Theater Command, Dept Neurosurg, Wuhan, Hubei, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Wang, Shuochen
Fu, Zhenghao
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Southern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Gen Hosp Cent Theater Command, Dept Neurosurg, Wuhan, Hubei, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Fu, Zhenghao
Sun, Yuanyi
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机构:
Southern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Gen Hosp Cent Theater Command, Dept Neurosurg, Wuhan, Hubei, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Sun, Yuanyi
Zhang, Meng
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机构:
Gen Hosp Cent Theater Command, Dept Neurosurg, Wuhan, Hubei, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Zhang, Meng
Chen, Aobo
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机构:
Univ Sci & Technol China, Affiliated Hosp 1, Dept Neurosurg, Hefei, Anhui, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Chen, Aobo
Cao, Chenglong
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Univ Sci & Technol China, Affiliated Hosp 1, Dept Neurosurg, Hefei, Anhui, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Cao, Chenglong
Song, Jian
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机构:
Southern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
Gen Hosp Cent Theater Command, Dept Neurosurg, Wuhan, Hubei, Peoples R ChinaSouthern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China
机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Wang, Bin
Fan, Yuanyuan
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机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Fan, Yuanyuan
Lu, Min
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机构:
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Lu, Min
Li, Shumei
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h-index: 0
机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Li, Shumei
Song, Zheng
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h-index: 0
机构:
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Song, Zheng
Peng, Xiaoling
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h-index: 0
机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Peng, Xiaoling
Zhang, Ruibin
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h-index: 0
机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Zhang, Ruibin
Lin, Qixiang
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机构:
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Lin, Qixiang
He, Yong
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机构:
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
He, Yong
Wang, Jun
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机构:
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Wang, Jun
Huang, Ruiwang
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机构:
S China Normal Univ, Key Lab Mental Hlth & Cognit Sci Guangdong Prov, Ctr Study Appl Psychol, Guangzhou 510631, Guangdong, Peoples R ChinaBeijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
机构:
Univ Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USAUniv Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
Rigon, Arianna
Duff, Melissa C.
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机构:
Univ Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
Univ Iowa, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
Duff, Melissa C.
McAuley, Edward
论文数: 0引用数: 0
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机构:
Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA
Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL USAUniv Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
McAuley, Edward
Kramer, Arthur F.
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机构:
Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USAUniv Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
Kramer, Arthur F.
Voss, Michelle W.
论文数: 0引用数: 0
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机构:
Univ Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA
Univ Iowa, Dept Psychol & Brain Sci, Iowa City, IA 52242 USAUniv Iowa, Neurosci Grad Program, WJSHC 250 Hawkins Dr, Iowa City, IA 52242 USA