Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

被引：19

作者：

Battaglia, Edda

Bassotti, Gabrio

Bellone, Graziella

Dughera, Luca

Serra, Anna Maria

Chiusa, Luigi

Repici, Alessandro

Mioli, Pierroberto

Emanuelli, Giorgio

机构：

[1] Univ Turin, Dept Gastroenterol & Clin Nutr, I-10124 Turin, Italy

[2] Univ Turin, Dept Biomed Sci & Human Oncol, I-10124 Turin, Italy

[3] San Giovanni Battista Hosp, Dept Emergency, Surg Unit, Turin, Italy

[4] Univ Perugia, Dept Clin & Expt Med, Gastroenterol Sect, I-06100 Perugia, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 38期

关键词：

C-Kit; gastroparesis; interstitial cells of Cajal; stem cell factor;

D O I：

10.3748/wjg.v12.i38.6172

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS: Gastric pacemaker cells expressing Kit receptor had completely. disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative. (C) 2006 The WJG Press. All rights reserved.

引用

页码：6172 / 6177

页数：6

共 57 条

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