Strategies for Cardiac Regeneration and Repair

被引：99
|
作者：
Lin, Zhiqiang [1 ]
Pu, William T. [1 ,2 ]
机构：
[1] Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA
[2] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期
关键词：
ACUTE MYOCARDIAL-INFARCTION; CARDIOSPHERE-DERIVED CELLS; ZEBRAFISH HEART REGENERATION; DE-NOVO CARDIOMYOCYTES; EMBRYONIC STEM-CELLS; BONE-MARROW; PROGENITOR CELLS; ISCHEMIC CARDIOMYOPATHY; MONONUCLEAR-CELLS; IN-VITRO;
D O I：
10.1126/scitranslmed.3006681
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable to overcome the fundamental problem of regenerating lost cardiomyocytes. Several strategies for promoting heart regeneration have emerged from decades of intensive study. Although some of these strategies remain confined to basic research, others are beginning to be tested in humans. We review strategies for cardiac regeneration and summarize progress of related clinical trials.
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页数：11
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