Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resistance reversal agents

被引：27

作者：

Millet, J

Torrentino-Madamet, M

Alibert, S

Rogier, C

Santelli-Rouvier, C

Mosnier, J

Baret, E

Barbe, J

Parzy, D

Pradines, B

机构：

[1] IMTSSA, Unite Parasitol, F-13998 Marseille, France

[2] Fac Pharm Marseille, GERCTOP, UMR CNRS 6009, Marseille, France

[3] Inst Federat Rech 48, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 07期

关键词：

D O I：

10.1128/AAC.48.7.2753-2756.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24 chloroquine-resistant and 10 chloroquine-susceptible strains of Plasmodium falciparum from different countries. The 9,10-dihydroethanoanthracene derivatives clearly increase chloroquine susceptibility only in chloroquine-resistant isolates.

引用

收藏

页码：2753 / 2756

页数：4

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