Ubiquitin-specific protease 4 predicts an unfavorable prognosis and promotes malignant behaviors in vitro in pancreatic cancer

被引：6

作者：

Wang, Yizhi ^{[1
]}

Zhou, Li ^{[1
]}

Lu, Jun ^{[1
]}

Jiang, Bolun ^{[1
]}

Liu, Chengxi ^{[1
]}

Liang, Zhiyong ^{[2
]}

Zhou, Weixun ^{[2
]}

Guo, Junchao ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gen Surg, 1 Shuaifuyuan Rd, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Pathol, Beijing 100730, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2020年 / 396卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ubiquitin-specific protease 4; Pancreatic cancer; Prognosis; TNF receptor associated factor 6; NF-kappa B signaling pathway; K-48-LINKED DEUBIQUITINATION; HEPATOCELLULAR-CARCINOMA; USP4; PROGRESSION; TRAF6; STABILIZATION; METASTASIS; ACTIVATION; EXPRESSION; APOPTOSIS;

D O I：

10.1016/j.yexcr.2020.112317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitin-specific protease 4 (USP4), has been reported to participate in the progression of various cancers due to its role in post-translational modulation. However, the prognostic significance and mechanism of USP4 in pancreatic cancer (PC) have not been well elucidated before. In the present study, we found that USP4 expression was higher in PC tissues than that in adjacent normal tissues and PC patients with high level of USP4 expression have a poor prognosis via immunohistochemistry and bioinformatics analyses. In vitro study showed that knockdown of USP4 inhibited PC cells proliferation, migration and invasion. Mechanistically, USP4 can activate nuclear factor kappa-B signaling pathway via stabilizing TNF receptor associated factor 6 at its protein level to promote the ability of proliferation, migration and invasion of PC cells. The results of this study revealed that USP4 plays a tumor-promoting role in PC and can be used as a prognostic indicator and therapeutic target for patients with resected PC.

引用

页数：12

共 45 条

[1]

Cao WH, 2016, EUR REV MED PHARMACO, V20, P1115

[2] USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation [J].

Fan, Y-H ;

Yu, Y. ;

Mao, R-F ;

Tan, X-J ;

Xu, G-F ;

Zhang, H. ;

Lu, X-B ;

Fu, S-B ;

Yang, J. .

CELL DEATH AND DIFFERENTIATION, 2011, 18 (10) :1547-1560

[3] Deubiquitinases in cancer: new functions and therapeutic options [J].

Fraile, J. M. ;

Quesada, V. ;

Rodriguez, D. ;

Freije, J. M. P. ;

Lopez-Otin, C. .

ONCOGENE, 2012, 31 (19) :2373-2388

[4] A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis [J].

Geng, Nanxi ;

Li, Yang ;

Zhang, Wenyu ;

Wang, Fei ;

Wang, Xu ;

Jin, Zining ;

Xing, Yao ;

Li, Danni ;

Zhang, Hongyan ;

Li, Yanshu ;

Li, Xiaodong ;

Cheng, Maosheng ;

Jin, Feng ;

Li, Feng .

INTERNATIONAL JOURNAL OF CANCER, 2020, 146 (04) :1139-1151

[5] The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction [J].

Glickman, MH ;

Ciechanover, A .

PHYSIOLOGICAL REVIEWS, 2002, 82 (02) :373-428

[6] The spatial and temporal organization of ubiquitin networks [J].

Grabbe, Caroline ;

Husnjak, Koraljka ;

Dikic, Ivan .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (05) :295-307

[7] Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells [J].

Guo, Zhixiang ;

Xu, Peng ;

Ge, Shangqing ;

Zhang, Chengxin ;

Zheng, Xiaoyan ;

Xu, Jinguo ;

Liu, Zhuang ;

Li, Bin ;

Ge, Shenglin .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 40 (04) :979-986

[8] USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation [J].

Hou, Pingping ;

Ma, Xingdi ;

Zhang, Qiang ;

Wu, Chang-Jiun ;

Liao, Wenting ;

Li, Jun ;

Wang, Huamin ;

Zhao, Jun ;

Zhou, Xin ;

Guan, Carolyn ;

Ackroyd, Jeffery ;

Jiang, Shan ;

Zhang, Jianhua ;

Spring, Denise J. ;

Wang, Y. Alan ;

DePinho, Ronald A. .

GENES & DEVELOPMENT, 2019, 33 (19-20) :1361-1366

[9] Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma [J].

Hou, Xiaozhi ;

Wang, Lijuan ;

Zhang, Lei ;

Pan, Xinliang ;

Zhao, Wei .

FEBS LETTERS, 2013, 587 (04) :311-316

[10] Pancreatic cancer [J].

Kleeff, Jorg ;

Korc, Murray ;

Apte, Minoti ;

La Vecchia, Carlo ;

Johnson, Colin D. ;

Biankin, Andrew V. ;

Neale, Rachel E. ;

Tempero, Margaret ;

Tuveson, David A. ;

Hruban, Ralph H. ;

Neoptolemos, John P. .

NATURE REVIEWS DISEASE PRIMERS, 2016, 2

← 1 2 3 4 5 →