Postural stabilization and balance assessment in Charcot-Marie-Tooth 1A subjects

被引:27
作者
Lencioni, T. [1 ]
Rabuffetti, M. [1 ]
Piscosquito, G. [2 ]
Pareyson, D. [2 ]
Aiello, A. [3 ]
Di Sipio, E. [4 ]
Padua, L. [4 ]
Stra, F. [5 ]
Ferrarin, M. [1 ]
机构
[1] Fdn Don Carlo Gnocchi, IRCCS, Biomed Technol Dept, I-20148 Milan, Italy
[2] IRCCS Fdn, C Besta Neurol Inst, Unit Clin Cent & Peripheral Degenerat Neuropathie, Milan, Italy
[3] Univ Genoa, Dept Neurosci Ophthalmol & Genet, Genoa, Italy
[4] Fdn Don Gnocchi Onlus, Ctr S Maria Della Pace, Rome, Italy
[5] Fdn Don Gnocchi Onlus, Sarzana, Italy
关键词
Charcot-Marie-Tooth; Balance; Posture; Muscle strength; Plantar flexion; BODY SWAY; GAIT; NEUROPATHY; FIBERS; STANCE;
D O I
10.1016/j.gaitpost.2014.07.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aim of the present study was to assess postural stabilization skill in adult subjects affected by Charcot-Marie-Tooth disease (CMT) type 1A. For this purpose ground reaction force (GRF) was measured by means of a piezoelectric force platform during the sit-to-stand (STS) movement, until a steady state erect posture was achieved. Specific indexes to quantify Centre of Mass acceleration, both during postural stabilization and during quiet standing, were computed using a mathematical model. Forty-seven CMT1A subjects were recruited for the study, and the control group was formed by forty-one age-and sex-matched healthy subjects. The results show that CMT1A subjects are less stable than controls during the quiet stance. Greater difficulty (high values of Y-inf, the final instability rate) to maintain erect posture appears to be mainly associated with plantar-flexor muscle weakness, rather than to damage of the proprioceptive system. The worst performances shown by CMT1A subjects in the stabilization phase (high values of I, the global index of postural stabilization performance) seem to be associated with reduced muscle strength and the loss of large sensory nerve fibres. Distal muscle weakness appears to affect both postural stabilization and quiet erect posture. The presented protocol and the analysis of postural stabilization parameters provide useful information on CMT1A balance disorders. (C) 2014 The Authors. Published by Elsevier B. V. This is an open access article under the CC BY license
引用
收藏
页码:481 / 486
页数:6
相关论文
共 29 条
  • [1] BODY SWAY AND VIBRATION PERCEPTION THRESHOLDS IN NORMAL AGING AND IN PATIENTS WITH POLYNEUROPATHY
    BERGIN, PS
    BRONSTEIN, AM
    MURRAY, NMF
    SANCOVIC, S
    ZEPPENFELD, K
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1995, 58 (03) : 335 - 340
  • [2] Campbell M. J., 2009, STAT SQUARE ONE, V11th
  • [3] Methodological considerations of existing techniques for determining stabilization times following a multi-planar transition
    DiDomenico, Angela
    McGorry, Raymond W.
    Banks, Jacob J.
    [J]. GAIT & POSTURE, 2013, 38 (03) : 541 - 543
  • [4] Foot drop and plantar flexion failure determine different gait strategies in Charcot-Marie-Tooth patients
    Don, Romildo
    Serrao, Mariano
    Vinci, Paolo
    Ranavolo, Alberto
    Cacchio, Angelo
    Ioppolo, Francesco
    Paoloni, Marco
    Procaccianti, Rita
    Frascarelli, Flaminia
    De Santis, Fablo
    Pierelli, Francesco
    Frascarelli, Massimo
    Santilli, Valter
    [J]. CLINICAL BIOMECHANICS, 2007, 22 (08) : 905 - 916
  • [5] Dyck P., 1993, PERIPHERAL NEUROPATH, V3rd, P1094
  • [6] DYCK PJ, 1972, HDB EEG CLIN NEUROPH, V9, P83
  • [7] Etnyre B, 2007, PHYS THER, V87, P12
  • [8] Gait pattern classification in children with Charcot-Marie-Tooth disease type 1A
    Ferrarin, M.
    Bovi, G.
    Rabuffetti, M.
    Mazzoleni, P.
    Montesano, A.
    Pagliano, E.
    Marchi, A.
    Magro, A.
    Marchesi, C.
    Pareyson, D.
    Moroni, I.
    [J]. GAIT & POSTURE, 2012, 35 (01) : 131 - 137
  • [9] Ferrarin M, 2009, GAIT POSTURE, V30, pS40
  • [10] Changes of gait pattern in children with Charcot-Marie-Tooth disease type 1A: a 18 months follow-up study
    Ferrarin, Maurizio
    Lencioni, Tiziana
    Rabuffetti, Marco
    Moroni, Isabella
    Pagliano, Emanuela
    Pareyson, Davide
    [J]. JOURNAL OF NEUROENGINEERING AND REHABILITATION, 2013, 10