Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

被引：419

作者：

Sturm, Dominik ^{[1
,2
]}

Bender, Sebastian ^{[1
,2
]}

Jones, David T. W. ^{[1
]}

Lichter, Peter ^{[3
]}

Grill, Jacques ^{[4
]}

Becher, Oren ^{[5
]}

Hawkins, Cynthia ^{[6
]}

Majewski, Jacek ^{[7
,8
,9
]}

Jones, Chris ^{[10
,11
]}

Costello, Joseph F. ^{[12
]}

Iavarone, Antonio ^{[13
,14
,15
]}

Aldape, Kenneth ^{[16
]}

Brennan, Cameron W. ^{[17
,18
]}

Jabado, Nada ^{[7
,8
,9
]}

Pfister, Stefan M. ^{[1
,2
]}

机构：

[1] German Canc Res Ctr DKFZ Heidelberg, Div Pediat Neurooncol, D-69120 Heidelberg, Germany

[2] Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, D-69120 Heidelberg, Germany

[3] German Canc Res Ctr DKFZ Heidelberg, Div Mol Genet, D-69120 Heidelberg, Germany

[4] Univ Paris 11, Gustave Roussy Canc Inst, Dept Pediat & Adolescent Oncol, Brain Tumor Program, F-94805 Villejuif, France

[5] Duke Univ, Med Ctr, Div Pediat Hematol Oncol, Durham, NC 27710 USA

[6] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada

[7] McGill Univ, Div Expt Med, Montreal, PQ H3H 2R9, Canada

[8] McGill Univ, Dept Human Genet, Montreal, PQ H3H 2R9, Canada

[9] McGill Univ, Ctr Hlth, Montreal, PQ H3H 2R9, Canada

[10] Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England

[11] Inst Canc Res, Div Canc Therapeut, Sutton SM2 5NG, Surrey, England

[12] Univ Calif San Francisco, Dept Neurosurg, Brain Tumor Res Ctr, San Francisco, CA 94143 USA

[13] Columbia Univ, Med Ctr, Inst Canc Genet, New York, NY 10032 USA

[14] Columbia Univ, Med Ctr, Dept Pathol, New York, NY 10032 USA

[15] Columbia Univ, Med Ctr, Dept Neurol, New York, NY 10032 USA

[16] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

[17] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[18] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, Dept Neurosurg, New York, NY 10065 USA

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 02期

关键词：

GROWTH-FACTOR RECEPTOR; TERT PROMOTER MUTATIONS; HIGH-GRADE GLIOMAS; PHASE-II TRIAL; INTEGRATED GENOMIC ANALYSIS; INTRINSIC PONTINE GLIOMAS; BRAIN-TUMOR CONSORTIUM; TYROSINE KINASE GENES; DNA MISMATCH REPAIR; NEURAL STEM-CELLS;

D O I：

10.1038/nrc3655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

引用

页码：92 / 107

页数：16

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