Oncolytic Virotherapy of Canine and Feline Cancer

被引：28

作者：

Gentschev, Ivaylo ^{[1
,2
]}

Patil, Sandeep S. ^{[1
]}

Petrov, Ivan ^{[1
]}

Cappello, Joseph ^{[2
]}

Adelfinger, Marion ^{[1
]}

Szalay, Aladar A. ^{[1
,2
,3
]}

机构：

[1] Univ Wurzburg, Dept Biochem, D-97074 Wurzburg, Germany

[2] Genelux Corp, San Diego Sci Ctr, San Diego, CA 92109 USA

[3] Univ Calif San Diego, Rebecca & John Moores Comprehens Canc Ctr, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA

来源：

VIRUSES-BASEL | 2014年 / 6卷 / 05期

关键词：

cancer; canine and feline cancer therapy; oncolytic virus; oncolysis; HERPES-SIMPLEX-VIRUS; CELL-BASED DELIVERY; VACCINIA VIRUS; THYMIDINE KINASE; GENE-THERAPY; TUMOR-CELLS; NUDE-MICE; IN-VITRO; PET DOGS; ADENOVIRUS;

D O I：

10.3390/v6052122

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer.

引用

页码：2122 / 2137

页数：16

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