Overview ofSalvia miltiorrhizaas a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

被引：59
作者：
Jung, Inyong [1 ]
Kim, Hyerin [1 ]
Moon, Seongcheol [1 ]
Lee, Hyuk [1 ]
Kim, Bonglee [1 ,2 ]
机构：
[1] Kyung Hee Univ, Coll Korean Med, Seoul 05253, South Korea
[2] Kyung Hee Univ, Korean Med Based Drug Repositioning Canc Res Ctr, Coll Korean Med, Seoul 05253, South Korea
来源：
ANTIOXIDANTS | 2020年 / 9卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
Salvia miltiorrhizaBunge; dansam; cancer; cardiovascular diseases; liver diseases; nervous system diseases; anti-inflammation; antioxidant; FATTY LIVER-DISEASE; SALVIANOLIC-ACID-B; ALZHEIMERS-DISEASE; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; HEART-DISEASE; CANCER CELLS; LUNG-CANCER; EXTRACT; DANSHEN;
D O I：
10.3390/antiox9090857
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Salvia miltiorrhizaBunge (S. miltiorrhiza) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets ofS. miltiorrhiza, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties ofS. miltiorrhizadiscussed in this article support the efficacy ofS. miltiorrhizaextract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects.
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页码：1 / 40
页数：40
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