Evidence for Camel-to-Human Transmission of MERS Coronavirus

被引：651

作者：

Azhar, Esam I. ^{[1
,2
]}

El-Kafrawy, Sherif A. ^{[2
]}

Farraj, Suha A. ^{[2
]}

Hassan, Ahmed M. ^{[2
]}

Al-Saeed, Muneera S. ^{[2
]}

Hashem, Anwar M. ^{[2
,3
]}

Madani, Tariq A. ^{[4
]}

机构：

[1] King Abdulaziz Univ, Dept Med Lab Technol, Fac Appl Med Sci, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Special Infect Agents Unit, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia

[3] King Abdulaziz Univ, Fac Med, Dept Med Microbiol & Parasitol, Jeddah 21589, Saudi Arabia

[4] King Abdulaziz Univ, Fac Med, Dept Med, Jeddah 21589, Saudi Arabia

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2014年 / 370卷 / 26期

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE-EAST; DROMEDARY CAMELS;

D O I：

10.1056/NEJMoa1401505

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel.

引用

页码：2499 / 2505

页数：7

共 16 条

[1]

[Anonymous], 2013, LAB TEST MIDDL E RES

[2] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus [J].

Assiri, Abdullah ;

McGeer, Allison ;

Perl, Trish M. ;

Price, Connie S. ;

Al Rabeeah, Abdullah A. ;

Cummings, Derek A. T. ;

Alabdullatif, Zaki N. ;

Assad, Maher ;

Almulhim, Abdulmohsen ;

Makhdoom, Hatem ;

Madani, Hossam ;

Alhakeem, Rafat ;

Al-Tawfiq, Jaffar A. ;

Cotten, Matthew ;

Watson, Simon J. ;

Kellam, Paul ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :407-416

[3]

Bermingham A, 2012, EUROSURVEILLANCE, V17, P6

[4]

Corman VM, 2012, EUROSURVEILLANCE, V17, P2

[5] Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study [J].

Cotten, Matthew ;

Watson, Simon J. ;

Kellam, Paul ;

Al-Rabeeah, Abdullah A. ;

Makhdoom, Hatem Q. ;

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Alhakeem, Rafat F. ;

Madani, Hossam ;

AlRabiah, Fahad A. ;

Al Hajjar, Sami ;

Al-Nassir, Wafa N. ;

Albarrak, Ali ;

Flemban, Hesham ;

Balkhy, Hanan H. ;

Alsubaie, Sarah ;

Palser, Anne L. ;

Gall, Astrid ;

Bashford-Rogers, Rachael ;

Rambaut, Andrew ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

LANCET, 2013, 382 (9909) :1993-2002

[6]

Guery B, 2013, LANCET, V381, P2254

[7] Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission [J].

Guery, Benoit ;

Poissy, Julien ;

el Mansouf, Loubna ;

Sejourne, Caroline ;

Ettahar, Nicolas ;

Lemaire, Xavier ;

Vuotto, Fanny ;

Goffard, Anne ;

Behillil, Sylvie ;

Enouf, Vincent ;

Caro, Valerie ;

Mailles, Alexandra ;

Che, Didier ;

Manuguerra, Jean-Claude ;

Mathieu, Daniel ;

Fontanet, Arnaud ;

van der Werf, Sylvie .

LANCET, 2013, 381 (9885) :2265-2272

[8] Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation [J].

Haagmans, Bart L. ;

Al Dhahiry, Said H. S. ;

Reusken, Chantal B. E. M. ;

Raj, V. Stalin ;

Galiano, Monica ;

Myers, Richard ;

Godeke, Gert-Jan ;

Jonges, Marcel ;

Farag, Elmoubasher ;

Diab, Ayman ;

Ghobashy, Hazem ;

Alhajri, Farhoud ;

Al-Thani, Mohamed ;

Al-Marri, Salih A. ;

Al Romaihi, Hamad E. ;

Al Khal, Abdullatif ;

Bermingham, Alison ;

Osterhaus, Albert D. M. E. ;

AlHajri, Mohd M. ;

Koopmans, Marion P. G. .

LANCET INFECTIOUS DISEASES, 2014, 14 (02) :140-145

[9] Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa [J].

Ithete, Ndapewa Laudika ;

Stoffberg, Samantha ;

Corman, Victor Max ;

Cottontail, Veronika M. ;

Richards, Leigh Rosanne ;

Schoeman, M. Corrie ;

Drosten, Christian ;

Drexler, Jan Felix ;

Preiser, Wolfgang .

EMERGING INFECTIOUS DISEASES, 2013, 19 (10) :1697-1699

[10] Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia [J].

Memish, Ziad A. ;

Mishra, Nischay ;

Olival, Kevin J. ;

Fagbo, Shamsudeen F. ;

Kapoor, Vishal ;

Epstein, Jonathan H. ;

AlHakeem, Rafat ;

Al Asmari, Mushabab ;

Islam, Ariful ;

Kapoor, Amit ;

Briese, Thomas ;

Daszak, Peter ;

Al Rabeeah, Abdullah A. ;

Lipkin, W. Ian .

EMERGING INFECTIOUS DISEASES, 2013, 19 (11) :1819-1823

← 1 2 →