Emerging Landscapes of Tumor Immunity and Metabolism

被引:11
作者
Wu, Fan [1 ]
Cheng, Ye [1 ]
Wu, Liangliang [1 ]
Zhang, Wenling [1 ,2 ]
Zheng, Wubing [1 ]
Wang, Qian [3 ]
Cao, Hongyong [1 ]
Pan, Xiongxiong [4 ]
Tang, Weiwei [1 ]
机构
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Gen Surg, Nanjing, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing, Peoples R China
[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Analyt Pathol, Neuherberg, Germany
[4] Nanjing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Nanjing, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2020年 / 10卷
关键词
cancer; metabolism; immunity; reprogram; drug resistance; T-CELL METABOLISM; MOLECULAR PATHWAYS; ANTITUMOR IMMUNITY; GLUTAMINE UPTAKE; CANCER; MEMORY; ACID; RESISTANCE; KINASE; EXPRESSION;
D O I
10.3389/fonc.2020.575037
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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页数:14
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