Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: systematic review

被引：14

作者：

Baydoun, Atallah ^{[1
,2
,3
]}

Traughber, Bryan ^{[4
,5
,6
]}

Morris, Nathan ^{[7
]}

Daou, Michella Abi Zeid ^{[8
]}

McGraw, Michael ^{[9
]}

Podder, Tarun K. ^{[3
,4
,5
]}

Muzic, Raymond F., Jr. ^{[3
,6
,10
]}

Lo, Simon S. ^{[11
]}

Ponsky, Lee E. ^{[12
]}

Machtay, Mitchell ^{[4
,5
]}

Ellis, Rodney ^{[4
,5
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Internal Med, Cleveland, OH USA

[2] Louis Stokes VA Med Ctr, Dept Internal Med, Cleveland, OH USA

[3] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Sch Med, Dept Radiat Oncol, Cleveland, OH USA

[5] Univ Hosp Seidman Canc Ctr, Dept Radiat Oncol, Cleveland, OH USA

[6] Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Case Ctr Imaging Res, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[8] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon

[9] Case Western Reserve Univ, Cleveland Hlth Sci Lib, Cleveland, OH 44106 USA

[10] Case Western Reserve Univ, Sch Med, Dept Radiol, Cleveland, OH USA

[11] Univ Washington, Sch Med, Dept Radiat Oncol, Seattle, WA USA

[12] Case Western Reserve Univ, Sch Med, Dept Urol, Cleveland, OH USA

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 07期

关键词：

brachytherapy; cryotherapy; focal therapy; HIFU; prostate cancer; SBRT; RADICAL PROSTATECTOMY; CONSENSUS; BRACHYTHERAPY; CRYOABLATION; CRYOSURGERY; INDEX;

D O I：

10.2217/fon-2016-0354

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCa). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCa in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCa seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCa. Prospero Registration Number: CRD42014014765.

引用

页码：649 / 663

页数：15

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