Role of LRRTMs in synapse development and plasticity

被引：42

作者：

Roppongi, Reiko T. ^{[1
,2
]}

Karimi, Benyamin ^{[1
,2
]}

Siddiqui, Tabrez J. ^{[1
,2
]}

机构：

[1] Univ Manitoba, Dept Physiol & Pathophysiol, Coll Med, Winnipeg, MB, Canada

[2] Hlth Sci Ctr, Kleysen Inst Adv Med, Neurosci Res Program, 710 William Ave, Winnipeg, MB R3Y 0Z3, Canada

来源：

NEUROSCIENCE RESEARCH | 2017年 / 116卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

LRRTM; Synapse development; Synaptic plasticity; Synapse formation; Autism; Schizophrenia; Neurodevelopment; Neural circuit; Neurexin; Heparan sulphate proteoglycan; HSPG; LEUCINE-RICH REPEAT; GENOME-WIDE ASSOCIATION; PROTEIN-TYROSINE PHOSPHATASES; AUTISM SPECTRUM DISORDER; CHINESE HAN POPULATION; NEUREXIN; GENE; CELL-ADHESION; PTP-SIGMA; TRANSMEMBRANE PROTEINS; EXCITATORY SYNAPSES;

D O I：

10.1016/j.neures.2016.10.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are a family of four synapse organizing proteins critical for the development and function of excitatory synapses. The genes encoding LRRTMs and their binding partners, neurexins and HSPGs, are strongly associated with multiple psychiatric disorders. Here, we review the literature covering their structural features, expression patterns in the developing and adult brains, evolutionary origins, and discovery as synaptogenic proteins. We also discuss their role in the development and plasticity of excitatory synapses as well as their disease associations. (C) 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

引用

页码：18 / 28

页数：11

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