Rapid and simple determination of methamphetamine and amphetamine in blood by simultaneous extraction-derivatization

被引：19
作者：
Sato, M
Mitsui, T
机构：
[1] Sci. Invest. Research Laboratory, Atchi Pref. Police H.Q., Naka-ku, Nagoya 460, 2-1-1, Sannomaru
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1997年 / 16卷 / 01期
关键词：
methamphetamine; amphetamine; pentafluorobenzyl derivatives; gas chromatography mass spectrometry; forensic toxicology;
D O I：
10.1016/S0731-7085(97)00012-5
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method capable of extracting and derivatising methamphetamine (MA) and amphetamine (AM) in blood simultaneously was developed. In this method ethyl acetate, triethylamine and pentafluorobenzyl bromide were added to blood, the extraction and pentafluorobenzyl derivatization of MA and AM were performed simultaneously by heating and stirring on a hot plate stirrer. Pentafluorobenzyl derivatives were determined by gas chromatography chemical ionization-mass spectrometry (GC/CI-MS). Deuterium labelled MA and AM were used as internal standards. This method enabled an accurate and precise quantitative analysis from blood containing MA and AM. Excellent results were obtained for autopsy cases with possible MA. (C) 1997 Elsevier Science B.V.
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页码：139 / 145
页数：7
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