UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?

被引：9
作者：
Cui, Ji-hong [1 ,2 ]
Xie, Xin [1 ,2 ,3 ]
机构：
[1] Northwest Univ, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian, Peoples R China
[2] Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China
[3] IIMI, Xian 710018, Peoples R China
来源：
INFLAMMATION | 2017年 / 40卷 / 02期
基金：
中国国家自然科学基金;
关键词：
UCH-L1; podocyte; lupus nephritis; NF-kappa B; TERMINAL HYDROLASE L1; NF-KAPPA-B; ACTIN-ASSOCIATED PROTEIN; URINARY PODOCYTES; COMPLEMENT-SYSTEM; RENAL-DISEASE; T-CELLS; INJURY; IDENTIFICATION; PATHOGENESIS;
D O I：
10.1007/s10753-017-0512-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs, and the most severe complication is lupus nephritis. Podocyte injury and loss play vital roles in the pathogenesis of lupus nephritis. Studies have shown that ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is involved in the pathogenesis and progression of many diseases, such as neurodegenerative disorders, cancers, and diabetes. Recently, numerous studies have indicated that UCH-L1 was upregulated in the podocytes in immune complex-mediated glomerulonephritis. This increase was correlated with disease aggravation. In this review, we discuss the role and mechanism of UCH-L1 in the pathogenesis of many diseases and, particularly, in lupus nephritis. Hence, we highlight the role of UCH-L1 in lupus nephritis.
引用
收藏
页码：657 / 665
页数：9
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