Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease

被引：5
作者：
Ju, Chun-Rong [1 ]
Zhang, Jian-Heng [1 ]
Chen, Miao [1 ]
Chen, Rong-Chang [1 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China
来源：
BIOMARKERS | 2017年 / 22卷 / 3-4期
关键词：
Chronic obstructive pulmonary disease; myostatin; pulmonary arterial hypertension; right ventricle; tricuspid annular plane systolic excursion; BRAIN NATRIURETIC PEPTIDE; SKELETAL-MUSCLE ATROPHY; 6-MINUTE WALK TEST; HYPERTENSION; COPD; ECHOCARDIOGRAPHY; PATHOPHYSIOLOGY; CARDIOMYOCYTES; EXPRESSION; MORTALITY;
D O I：
10.1080/1354750X.2016.1203999
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods: The study recruited 84 patients with AECOPD. Plasma myostatin was analyzed and tricuspid annular plane systolic excursion (TAPSE)<16mm was used as the main indicator for RVD.Results: Plasma myostatin levels were significantly higher in 47 patients with RVD than 37 ones without (P<0.005). Multivariate regression analysis revealed that myostatin levels correlated significantly with TAPSE values and RV myocardial performance index (p<0.001) among the study patients.Conclusion: Plasma myostatin is a potential biomarker for improving diagnosis of RVD in AECOPD.
引用
收藏
页码：246 / 252
页数：7
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