A Novel Application of Buprenorphine Transdermal Patch to Relieve Pain in the Knee Joint of Knee Osteoarthritis Patients: A Retrospective Case-Control Study

被引：3

作者：

Gil, Ho Young ^{[1
]}

Park, Sungchul ^{[2
]}

Kim, Na Eun ^{[3
]}

Choi, Yi Hwa ^{[4
]}

Kim, Jae Hyung ^{[5
]}

Choi, Sooil ^{[6
]}

Kim, Hyun Joong ^{[7
]}

Koh, Jae Chul ^{[8
]}

Lee, Byung Ho ^{[1
]}

Lee, Sook Young ^{[1
]}

Min, Sang Kee ^{[1
]}

Kim, Bora ^{[1
]}

Lee, Hye Seon ^{[1
]}

Jeong, Hae Won ^{[9
]}

Park, Ji Hyun ^{[10
]}

Park, Bumhee ^{[10
,11
]}

Choi, Jong Bum ^{[1
]}

机构：

[1] Ajou Univ, Sch Med, Dept Anesthesiol & Pain Med, Suwon 16499, South Korea

[2] Cha Univ, Sch Med, Cha Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam 13496, South Korea

[3] Inha Univ, Sch Med, Dept Anesthesiol & Pain Med, Incheon 22332, South Korea

[4] Hallym Univ, Coll Med, Hallym Sacred Heart Hosp, Dept Anesthesiol & Pain Med, Anyang 14068, South Korea

[5] Hallym Univ, Coll Med, Hallym Dongtan Sacred Heart Hosp, Dept Anesthesiol & Pain Med, Hwaseong 18450, South Korea

[6] Catholic Kwandong Univ, Coll Med, Int St Marys Hosp, Dept Anesthesiol & Pain Med, Incheon 22711, South Korea

[7] Korea Univ, Ansan Hosp, Dept Anesthesiol & Pain Med, Ansan 15355, South Korea

[8] Korea Univ, Anam Hosp, Dept Anesthesiol & Pain Med, Seoul 02841, South Korea

[9] Hwalgichan Orthoped Surg & Pain Clin, Seoul 03329, South Korea

[10] Ajou Univ, Med Ctr, Ajou Res Inst Innovat Med, Off Biostat, Suwon 16499, South Korea

[11] Ajou Univ, Sch Med, Dept Biomed Informat, Suwon 16499, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 07期

关键词：

buprenorphine; transdermal patch; osteoarthritis; knee; knee joint; INTRAARTICULAR MORPHINE;

D O I：

10.3390/jcm8071009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoarthritis (OA) is considered to be one of the most disabling diseases. The intra-articular opioid injection has been widely studied for its simplicity, safety, and efficacy in OA. In this study, however, we suggest a novel method of buprenorphine transdermal patch (BTDP) to painful knee joints of OA patients, instead of intra-articular opioid injection, and subsequently compared the knee application with conventional chest application. We retrospectively enrolled 213 patients with knee OA who did not respond to conventional therapy. The Numeric Rating Scale (NRS), adverse effects, and compliance were recorded before and after the application of the BTDP. All parameters were compared between the knee applied group and the chest applied group. After the BTDP application, the NRS score in the knee applied group was lower than that of the chest applied group (p = 0.007). NRS scores after buprenorphine patch decreased to 2.21 +/- 0.77, and 2.55 +/- 0.71 in the chest applied group and the knee applied group, respectively. The adverse effects were 19.32% in the knee applied group, and 64.00% in the chest applied group. The compliances were 82.95% and 37.60% in the knee applied group and chest applied group, respectively. This novel application of BTDP directly to the painful knee joint of knee OA patients led to a decrease in the NRS score, adverse effects, and an increase in compliance compared with the chest application method.

引用

页数：9

共 19 条

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