Elevated Transforming Growth Factor-β2 in the Aqueous Humor: A Possible Explanation for High Rate of Capsular Contraction Syndrome in High Myopia

被引：15

作者：

Zhang, Keke ^{[1
,2
,3
]}

Zhu, Xiangjia ^{[1
,2
,3
]}

Chen, Minjie ^{[1
,2
,3
]}

Sun, Xinghuai ^{[1
,2
,3
]}

Yang, Jin ^{[1
,2
,3
]}

Zhou, Peng ^{[4
,5
]}

Lu, Yi ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Ophthalmol, Eye & Ear Nose & Throat Hosp, 83 Fenyang Rd, Shanghai 200031, Peoples R China

[2] Minist Hlth, Key Lab Myopia, 83 Fenyang Rd, Shanghai 200031, Peoples R China

[3] Fudan Univ, Key Lab Visual Impairment & Restorat Shanghai, 83 Fenyang Rd, Shanghai 200031, Peoples R China

[4] Pkwy Hlth Specialty & Inpatient Ctr Luwan, Dept Ophthalmol, 170 DanShui Rd,Floor 3, Shanghai 200020, Peoples R China

[5] Pkwy Hlth Hong Qiao Med Ctr, 2258 Hong Qiao Rd, Shanghai 200335, Peoples R China

来源：

JOURNAL OF OPHTHALMOLOGY | 2016年 / 2016卷

基金：

中国国家自然科学基金;

关键词：

INTRAOCULAR-LENS; BETA; OPACIFICATION; IMPLANTATION; EXPRESSION; RECEPTOR;

D O I：

10.1155/2016/5438676

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose. The purpose of the study was to elucidate the role of transforming growth factor-beta 2 (TGF-beta 2) in the development of high myopic capsular contraction syndrome. Methods. Nineteen cases of capsular contraction syndrome, including 14 with high myopia, were collected, and their clinical data were reviewed. Aqueous humor and anterior capsular membranes were obtained during capsulotomy. Hematoxylin-eosin and immunohistochemical staining with anti-TGF-beta 2 antibody were performed on capsular membranes. TGF-beta 2 levels in aqueous humor were assayed using ELISA and western blot. Results. High myopia was significantly associated with the incidence of capsular contraction syndrome (odds ratio: 14.74, P < 0.001, 95% CI: 5.29-41.05). Histopathological analysis revealed proliferation of fibroblast-like lens epithelial cells on the shrunken anterior capsule, labeled with TGF-beta 2 antibodies. ELISA and Western blot showed higher levels of TGF-beta 2 in aqueous humor of patients with capsular contraction syndrome and high myopia. Conclusions. High myopia is a risk factor for capsular contraction syndrome. Elevated TGF-beta 2 levels in high myopic cataract patients may play an important role in the pathogenesis of capsular contraction syndrome.

引用

页数：6

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