Copper Nitrate Catalyzed Three-Component One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones

被引：8

作者：

Wang, Min ^{[1
]}

Jiang, Heng ^{[2
]}

Song, Zhiguo ^{[3
]}

Gong, Hong ^{[2
]}

机构：

[1] Bohai Univ, Coll Chem & Chem Engn, Jinzhou 121000, Liaoning, Peoples R China

[2] Liaoning Shihua Univ, Fushun, Liaoning, Peoples R China

[3] Bohai Univ, Ctr Sci & Technol Expt, Jinzhou 121000, Liaoning, Peoples R China

来源：

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | 2009年 / 39卷 / 04期

关键词：

Biginelli reaction; Copper nitrate; Dihydropyrimidinones; One-pot synthesis; SOLVENT-FREE CONDITIONS; BIGINELLI REACTION; EFFICIENT SYNTHESIS; REUSABLE CATALYST; ACID; CONDENSATION; CHLORIDE; METHANESULFONATE; ALDEHYDES; TRIFLATE;

D O I：

10.1080/10826060903209596

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones from aldehydes, 1,3-dicarbonyl compounds, and urea using copper nitrate under refluxing temperature in ethanol was described. Compared with other Lewis copper salts, copper nitrate proved to be the most efficient. The advantages of the new method were good yields (61-93%), short reaction time (0.4-3h), and inexpensive catalyst.

引用

页码：372 / 379

页数：8

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